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With an increasingly aging global population, greater numbers of OA patients are providing clear economic and societal burdens. Surgical and pharmacological treatments are the most common and conventional therapeutic strategies for OA, but often fall considerably short of desired or optimal outcomes. With the development of stimulus\u2010responsive nanoplatforms has come the potential for improved therapeutic strategies for OA. Enhanced control, longer retention time, higher loading rates, and increased sensitivity are among the potential benefits. This review summarizes the advanced application of stimulus\u2010responsive drug delivery nanoplatforms for OA, categorized by either those that depend on endogenous stimulus (reactive oxygen species, pH, enzyme, and temperature), or those that depend on exogenous stimulus (near\u2010infrared ray, ultrasound, magnetic fields). The opportunities, restrictions, and limitations related to these various drug delivery systems, or their combinations, are discussed in areas such as multi\u2010functionality, image guidance, and multi\u2010stimulus response. The remaining constraints and potential solutions that are represented by the clinical application of stimulus\u2010responsive drug delivery nanoplatforms are finally summarized.<\/jats:p>","DOI":"10.1002\/smll.202206929","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T05:21:29Z","timestamp":1678512089000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Stimulus\u2010Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy"],"prefix":"10.1002","volume":"19","author":[{"given":"Qi","family":"Jiang","sequence":"first","affiliation":[{"name":"Dr. Li Dak Sum &amp; Yip Yio Chin Center for Stem Cells and Regenerative Medicine Department of Orthopedic Surgery of the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310058 China"},{"name":"Zhejiang University\u2010University of Edinburgh Institute Zhejiang University School of Medicine Key Laboratory 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