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However, the potential risks brought by surgery, such as normal brain tissue damage, post\u2010operative infection, and difficulty in removing deep hematoma, are still the main problems in the surgical treatment of ICH. Activation of the peroxisome proliferator\u2010activated receptor gamma (PPAR\u03b3) is reported to show a good therapeutic effect in hematoma clearance. Herein, a magnetic targeting nanocarrier loaded with a PPAR\u03b3 agonist (15d\u2010PGJ2\u2010MNPs) is synthesized, which could be magnetically targeted and enriched in the area of the hematoma after intravenous injection. Subsequent application of focusing ultrasound (FUS) could enhance drug diffusion, which activates the PPAR\u03b3 receptors on macrophages around the hematoma for better hematoma clearance. The 15d\u2010PGJ2\u2010MNP treatment alleviates brain injury, accelerates hematoma clearance, attenuates neuroinflammation, reduces brain edema and significantly improves the deficits in sensory and motor function and spatial learning ability in the ICH mouse model. This work proposes an effective magnetic targeting plus FUS method to treat ICH, highlighting its great potential in the treatment of hemorrhagic stroke.<\/jats:p>","DOI":"10.1002\/smll.202206982","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T06:19:45Z","timestamp":1674800385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Magnetic Targeting Nanocarriers Combined with Focusing Ultrasound for Enhanced Intracerebral Hemorrhage Therapy"],"prefix":"10.1002","volume":"19","author":[{"given":"Tianyi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery &amp; Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow University  Suzhou Jiangsu Province 215006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Lei","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano &amp; 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