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Designing a delivery carrier according to the pathological characteristics of RA that can control drug release in response to disease severity may be a promising treatment strategy. Psoralen is the main active ingredient isolated from <jats:italic>Psoralea corylifolia<\/jats:italic> L. and possesses excellent anti\u2010inflammatory activities as well as improving bone homeostasis. However, the specific underlying mechanisms, particularly the possible relationships between the anti\u2010RA effects of psoralen and related metabolic network, remain largely unexplored. Furthermore, psoralen shows systemic side effects and has unsatisfactory solubility. Therefore, it is desirable to develop a novel delivery system to maximize psoralen's therapeutic effect. In this study, a self\u2010assembled degradable hydrogel platform is developed that delivers psoralen and calcium peroxide to arthritic joints and controls the release of psoralen and oxygen according to inflammatory stimulation, to regulate homeostasis and the metabolic disorder of the anoxic arthritic microenvironment. Therefore, the hydrogel drug delivery system based on the responsiveness of the inflammatory microenvironment and regulation of metabolism provides a new therapeutic strategy for RA treatment.<\/jats:p>","DOI":"10.1002\/smll.202207319","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T10:01:19Z","timestamp":1677924079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A Metabolic Driven Bio\u2010Responsive Hydrogel Loading Psoralen for Therapy of Rheumatoid Arthritis"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8237-0918","authenticated-orcid":false,"given":"Kexin","family":"Wang","sequence":"first","affiliation":[{"name":"National Key Clinical Specialty\/Engineering Technology Research Center of Education Ministry of China Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration Neurosurgery Institute Department of Neurosurgery Zhujiang Hospital Southern Medical University  Guangzhou 510000 P. 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