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Herein, the iron\u2010doped and oxygen\u2010deficient bismuth tungstate nanosheets (BWO\u2010Fe NSs) with piezotronic effect are synthesized for enhanced SDT. Due to the existence of oxygen defects introduced through Fe doping, the bandgap of BWO\u2010Fe is significantly narrowed so that BWO\u2010Fe can be more easily activated by exogenous ultrasound (US). The oxygen defects acting as the electron traps inhibit the recombination of US\u2010induced electrons and holes. More importantly, the dynamically renewed piezoelectric potential facilitates the migration of electrons and holes to opposite side and causes energy band bending, which further promotes the production of reactive oxygen species. Furthermore, Fe doping endows BWO\u2010Fe with Fenton reactivity, which converts hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) in tumor microenvironment into hydroxyl radicals (\u2022OH), thereby amplifying the cellular oxidative damage and enhancing SDT. Both in vitro and in vivo experiments illustrate their high cytotoxicity and tumor suppression rate against refractory breast cancer in mice. This work may provide an alternative strategy to develop oxygen\u2010deficient piezoelectric sonosensitizers for enhanced SDT via doping metal ions.<\/jats:p>","DOI":"10.1002\/smll.202300327","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T07:10:40Z","timestamp":1678864240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Enhanced Sonodynamic Cancer Therapy through Iron\u2010Doping and Oxygen\u2010Vacancy Engineering of Piezoelectric Bismuth Tungstate Nanosheets"],"prefix":"10.1002","volume":"19","author":[{"given":"Yiming","family":"Ding","sequence":"first","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences  Beijing 101400 P. R. 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