{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:52:21Z","timestamp":1788587541694,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071712"],"award-info":[{"award-number":["82071712"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873857"],"award-info":[{"award-number":["81873857"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071596"],"award-info":[{"award-number":["82071596"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101800"],"award-info":[{"award-number":["82101800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The damaged endometrium and the formation of fibrosis are key barriers to pregnancy and further lead to infertility. However, how to promote endometrium repair is always a challenge. Here, a bioactive injectable and self\u2010healing hydrogel is developed by physically combination of thiolated polyethylene (PEG), Cu<jats:sup>2+<\/jats:sup> and cell\u2010free fat extract (CEFFE, CF) for endometrial regeneration and fertility. By inheriting the advantages of various active proteins contained in CEFFE, it could induce the overall repair of endometrial microenvironment for intrauterine adhesion (IUA). In vitro, CF@Cu\u2010PEG reduces endometrial cell apoptosis by more than 50%, and increases angiogenesis by 92.8%. In the IUA mouse, injection of CF@Cu\u2010PEG significantly reduces the rate of uterine hydrometra and prevents the formation of endometrial fibrosis. Remarkably, CF@Cu\u2010PEG contributes to the repair of endometrial microstructure, especially increases the number of endometrial pinopodes, significantly improves endometrial receptivity, and increases the pregnancy rate of IUA mice from 7.14% to 66.67%. In summary, through the physically combination of CEFFE and Cu\u2010PEG, the construction of loaded bioactive injectable hydrogel not only inhibits the IUA, but also induces the self\u2010repair of endometrial cells in situ and improves fertility, providing a new strategy for IUA repair in clinical application.<\/jats:p>","DOI":"10.1002\/smll.202300481","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T09:47:32Z","timestamp":1681120052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Bioactive Injectable and Self\u2010Healing Hydrogel Via Cell\u2010Free Fat Extract for Endometrial Regeneration"],"prefix":"10.1002","volume":"19","author":[{"given":"Bufang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0568-1787","authenticated-orcid":false,"given":"Mengyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6938-9582","authenticated-orcid":false,"given":"Wenguo","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-1014-y"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202000963"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02813-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB01190H"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-03012-w"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.912648"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey232"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105175"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.02.096"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.12.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2001.801103.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000378"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey237"},{"key":"e_1_2_9_14_1","first-page":"6337","volume":"17","author":"Chi Y.","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.02.013"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0924-z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2022.07.003"},{"key":"e_1_2_9_18_1","first-page":"230","volume":"2","author":"Wang X. W.","year":"2021","journal-title":"Eng. Regener."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0735-7"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2016.11.008"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2021.08.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.894252"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2021.100101"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma11010166"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c04713"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801555"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.11.017"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2020.61.10.868"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.03.032"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2018.0283"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.11.016"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02258-0"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202007235"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201902099"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1739171"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00536"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjz306"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6146942"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab366"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902672"},{"key":"e_1_2_9_41_1","volume":"2020","author":"Lin X.","year":"2020","journal-title":"Research (Wash D C)"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.07.017"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182211998"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00052E"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00125-18"},{"key":"e_1_2_9_46_1","volume":"2019","author":"Chen G.","year":"2019","journal-title":"Research (Wash D C)"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.08.002"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.6b00371"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-1564-7"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110644"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.09.002"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey119"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202300481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T09:44:30Z","timestamp":1693475070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202300481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,10]]},"references-count":52,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/smll.202300481"],"URL":"https:\/\/doi.org\/10.1002\/smll.202300481","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,10]]},"assertion":[{"value":"2023-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300481"}}