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How the thin condylar fibrocartilage can achieve efficient energy dissipation to cushion enormous stresses remains an open question in biology and tissue engineering. Here,\u00a0three distinct zones in the condylar fibrocartilage are identified by analyzing the components and structure from the macro\u2010and microscale to the nanoscale. Specific proteins\u00a0are highly expressed in each zone related to its mechanics. The heterogeneity of condylar fibrocartilage can direct energy dissipation through the nano\u2010micron\u2013macro gradient spatial scale, by atomic force microscope (AFM), nanoindentation, dynamic mechanical analyzer assay (DMA), and the corresponding energy dissipation mechanisms\u00a0are exclusive for each distinct zone. This study reveals the significance of the heterogeneity of condylar fibrocartilage in mechanical behavior and provides new insights into the research methods for cartilage biomechanics and the design of energy\u2010dissipative materials.<\/jats:p>","DOI":"10.1002\/smll.202301051","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T02:46:27Z","timestamp":1683600387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Spatial Heterogeneity Directs Energy Dissipation in Condylar Fibrocartilage"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9221-9568","authenticated-orcid":false,"given":"Nan","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases Department of Oral and Maxillofacial Surgery West China Hospital of Stomatology Sichuan University  Chengdu 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