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Due to delayed presentation, gynecological cancer patients are often referred late in the disease's course, resulting in poor outcomes. A considerable number of patients ultimately succumb to chemotherapy\u2010resistant disease, which reoccurs at advanced stages despite treatment interventions. Although efforts have been devoted to developing therapies that demonstrate reduced resistance to chemotherapy and enhanced toxicity profiles, current clinical outcomes remain unsatisfactory due to treatment resistance and unfavorable off\u2010target effects. Consequently, innovative biological and nanotherapeutic approaches are imperative to strengthen and optimize the therapeutic arsenal for gynecological cancers. Advancements in nanotechnology\u2010based therapies for gynecological malignancies offer significant advantages, including reduced toxicity, expanded drug circulation, and optimized therapeutic dosing, ultimately leading to enhanced treatment effectiveness. Recent advances in nucleic acid therapeutics using microRNA, small interfering RNA, and messenger RNA provide novel approaches for cancer therapeutics. Effective single\u2010agent and combinatorial nucleic acid therapeutics for gynecological malignancies have the potential to transform cancer treatment by giving safer, more tailored approaches than conventional therapies. This review highlights current preclinical studies that effectively exploit these approaches for the treatment of gynecological malignant tumors and malignant ascites.<\/jats:p>","DOI":"10.1002\/smll.202301776","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T02:10:32Z","timestamp":1690769432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development and Perspectives: Multifunctional Nucleic Acid Nanomedicines for Treatment of Gynecological Cancers"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-2778","authenticated-orcid":false,"given":"Tetiana","family":"Korzun","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Oregon State University 2730 S Moody Avenue Portland OR 97201 USA"},{"name":"Department of Biomedical Engineering Oregon Health &amp; Science University 3303 SW Bond Avenue Portland Portland OR 97239 USA"},{"name":"Medical Scientist Training Program Oregon Health &amp; 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