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Despite its potential for a wide range of applications, the intrinsic quantitative nature of MPI has not been fully exploited in biological environments. In this study,\u00a0a novel NP architecture that overcomes this limitation by maintaining a virtually unchanged effective relaxation (Brownian plus N\u00e9el) even when immobilized is presented. This superparamagnetic magnetite architecture made of phenolic resin hollow spheres coated with Eu(III) containing silica nanoparticles (SMART RHESINs)\u00a0was\u00a0synthesized and studied. Magnetic particle spectroscopy (MPS) measurements confirm their suitability for potential MPI applications. Photobleaching studies show an unexpected photodynamic due to the fluorescence emission peak of the europium ion in combination with the phenol formaldehyde resin (PFR). Cell metabolic activity and proliferation behavior are not affected. Colocalization experiments reveal\u00a0the distinct accumulation of SMART RHESINs near the Golgi apparatus. Overall, SMART RHESINs show superparamagnetic behavior and special luminescent properties without acute cytotoxicity, making them suitable for bimodal imaging probes for medical use like cancer diagnosis and treatment. SMART RHESINs have the potential to enable quantitative MPS and MPI measurements both in mobile and immobilized environments.<\/jats:p>","DOI":"10.1002\/smll.202301997","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T06:19:09Z","timestamp":1684477149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["SMART RHESINs\u2014Superparamagnetic Magnetite Architecture Made of Phenolic Resin Hollow Spheres Coated with Eu(III) Containing Silica Nanoparticles for Future Quantitative Magnetic Particle Imaging Applications"],"prefix":"10.1002","volume":"19","author":[{"given":"Julia","family":"Feye","sequence":"first","affiliation":[{"name":"Faculty of Engineering Baden\u2010W\u00fcrttemberg Cooperative State University Karlsruhe  76133 Karlsruhe Germany"},{"name":"Institute of Inorganic Chemistry Karlsruhe Institute of Technology  76131 Karlsruhe 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