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Herein, a bilayered hydrogel tube based on the essential structure of native blood vessels is\u00a0developed by optimizing the relation between vascular functions and the molecular structure of hydrogels. The inner layer of the SDVGs comprises a zwitterionic fluorinated hydrogel, avoiding the formation of thromboinflammation\u2010induced mural thrombi. Furthermore, the position and morphology of the SDVGs can\u00a0be visualized via <jats:sup>19<\/jats:sup>F\/<jats:sup>1<\/jats:sup>H magnetic resonance imaging. The outer poly(<jats:italic>N\u2010<\/jats:italic>acryloyl glycinamide) hydrogel layer of SDVGs provides matched mechanical properties with native blood vessels through the multiple and controllable intermolecular hydrogen\u2010bond interactions, which can\u00a0withstand the accelerated fatigue test under pulsatile radial pressure for 380 million cycles (equal to a service life of 10 years in vivo). Consequently, the SDVGs exhibit higher patency (100%) and more stable morphology following porcine carotid artery transplantation for 9 months and rabbit carotid artery transplantation for 3 months. Therefore, such a bioinspired, antithrombotic, and visualizable SDVG presents a promising design approach for long\u2010term patency products and great potential of helping patients with cardiovascular diseases.<\/jats:p>","DOI":"10.1002\/smll.202302621","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T04:44:40Z","timestamp":1687322680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Bioinspired, Anticoagulative, <sup>19<\/sup>F MRI\u2010Visualizable Bilayer Hydrogel Tubes as High Patency Small\u2010Diameter Vascular Grafts"],"prefix":"10.1002","volume":"19","author":[{"given":"Shuangyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Polymer Science and Engineering Key Laboratory of Systems Bioengineering (Ministry of Education) School of Chemical Engineering and Technology Tianjin University Tianjin 300072 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