{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:13:02Z","timestamp":1784041982762,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"50","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071384"],"award-info":[{"award-number":["32071384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2102300"],"award-info":[{"award-number":["2021YFC2102300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cancer vaccines generally are limited by insufficient tumor\u2010specific cellular immunogenicity. Herein, a potent \u201cABC\u201d ternary membrane\u2010derived vaccine system blended from antigen\u2010presenting mature dendritic cell membranes (\u201cA\u201d), bacterial <jats:italic>E. coli<\/jats:italic> cytoplasmic membranes (\u201cB\u201d), and cancer cell membranes (\u201cC\u201d) is developed using a block\u2010copolymer micelle\u2010enabled approach. The respective ABC membrane components provide for a source of cellular immune communication\/activation and enhanced accumulation in lymph nodes (A), immunological adjuvant (B), and tumor antigens (C). The introduction of dendritic cell (DC) membranes enables multiple cell\u2010to\u2010cell communication and powerful immune activation. ABC activates dendritic cells and promotes T\u2010cell activation and proliferation in vitro. In vivo, ABC is 14\u2010 and 304\u2010fold more immunogenic than binary (BC) and single (C) membrane vaccines, and immunization with ABC enhances the frequency of tumor\u2010specific cytotoxic T lymphocytes, leading to an 80% cure rate in tumor\u2010bearing mice. In a surgical resection and recurrence model, ABC prevents recurrence with vaccination from autologous cancer membranes, and therapeutic effects are observed in a lung metastasis model even with heterologous cancer cell membranes. ABCs formed from human cancer patient\u2010derived tumor cells activate human monocyte\u2010derived dendritic cells (moDC). Taken together, the ternary ABC membrane system provides the needed functional components for personalized cancer immunotherapy.<\/jats:p>","DOI":"10.1002\/smll.202302756","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:05:11Z","timestamp":1692677111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Anti\u2010Tumor Immunity Induced by a Ternary Membrane System Derived From Cancer Cells, Dendritic Cells, and Bacteria"],"prefix":"10.1002","volume":"19","author":[{"given":"He","family":"Ren","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Technology Key Laboratory of Systems Bioengineering (Ministry of Education) Tianjin University  Tianjin 300350 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Department of Breast Cancer Tianjin Medical University Cancer Institute and Hospital Key Laboratory of Breast Cancer Prevention and Therapy Ministry of Education Key Laboratory of Cancer Prevention and Therapy National Clinical Research Center for Cancer  Tianjin 300060 P. R. 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