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Currently, available treatment options have limited efficacy and are associated with adverse effects due to biological barriers and clearance mechanisms. To address this challenge, a novel topical delivery system is developed\u2014Gel <jats:bold>2_1&amp;Eylea<\/jats:bold>\u2014an aflibercept\u2010loaded eye\u2010drop hydrogel mediated with cell\u2010penetrating peptide <jats:bold>1<\/jats:bold>. Gel <jats:bold>2_1&amp;Eylea<\/jats:bold> demonstrates superior membrane permeability, increased stability, and prolonged drug retention time on the ocular surface, and thus may improve drug efficacy. In a rabbit CoNV model, Gel <jats:bold>2_1&amp;Eylea<\/jats:bold> significantly reduces the density of neovascularization with no adverse effects on normal corneoscleral limbal vessels, demonstrating high efficacy and biocompatibility. This work identifies a promising treatment for CoNV which has the potential to benefit other ocular neovascular diseases.<\/jats:p>","DOI":"10.1002\/smll.202302765","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T01:40:57Z","timestamp":1694137257000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Aflibercept Loaded Eye\u2010Drop Hydrogel Mediated with Cell\u2010Penetrating Peptide for Corneal Neovascularization Treatment"],"prefix":"10.1002","volume":"20","author":[{"given":"Jianan","family":"Zhou","sequence":"first","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics School of Biomedical Sciences Hunan University  Changsha Hunan 410082 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