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Microwave therapy is widely studied due to its remarkable ability to penetrate deep tissue. This paper focuses on the development of a microwave\u2010responsive system, namely, a zinc ion (Zn\n                    <jats:sup>2+<\/jats:sup>\n                    ) doped graphite carbon nitride (CN) system (BZCN), achieved through two high\u2010temperature burning processes. By subjecting composite materials to microwave irradiation, an impressive 99.81% eradication of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    is observed within 15\u00a0min. Moreover, this treatment enhances the growth of bone marrow stromal cells. The Zn\n                    <jats:sup>2+<\/jats:sup>\n                    doping effectively alters the electronic structure of CN, resulting in the generation of a substantial number of free electrons on the material's surface. Under microwave stimulation, sodium ions collide and ionize with the free electrons generated by BZCN, generating a large amount of energy, which reacts with water and oxygen, producing reactive oxygen species. In addition, Zn\n                    <jats:sup>2+<\/jats:sup>\n                    doping improves the conductivity of CN and increases the number of unsaturated electrons. Under microwave irradiation, polar molecules undergo movement and generate frictional heat. Finally, the released Zn\n                    <jats:sup>2+<\/jats:sup>\n                    promotes macrophages to polarize toward the M2 phenotype, which is beneficial for tibial repair.\n                  <\/jats:p>","DOI":"10.1002\/smll.202303484","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:17:20Z","timestamp":1690157840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Metal Ion Coordination Improves Graphite Nitride Carbon Microwave Therapy in Antibacterial and Osteomyelitis Treatment"],"prefix":"10.1002","volume":"19","author":[{"given":"Bo","family":"Li","sequence":"first","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan 430062 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan 430062 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelin","family":"Lv","sequence":"additional","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan 430062 P. R. 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