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Considering the location of cervical cancer, access to the cervix through the vagina may provide an alternative administration route for high drug amounts at the tumor site, minimal systemic exposure as well as convenience of non\u2010invasive self\u2010medication. Enormous progress has been made in nanomedicine to improve mucosal penetration and enhance the effectiveness of therapy for cervical cancer. This review article first introduce the physiological state of cervicovaginal cavity and the characteristics of intravaginal environment in cervical cancers. Based on introduction to the physiological state of cervicovaginal cavity and the characteristics of intravaginal environment in cervical cancers, both \u201cfirst mucus\u2010adhering then mucosal penetration\u201d and \u201cfirst mucus\u2010penetrating then mucosal penetration\u201d strategies are discussed with respect to mechanism, application condition, and examples. Finally, existing challenges and future directions are envisioned in the rational design, facile synthesis, and comprehensive utilization of nanomedicine for local therapy of cervical cancer. This review is expected to provide useful reference information for future research on nanomedicine for intravaginally administered formulations for topical treatment of cervical cancer.<\/jats:p>","DOI":"10.1002\/smll.202303772","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T04:39:04Z","timestamp":1687322344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Advance in Nanomedicine for Improving Mucosal Penetration and Effective Therapy of Cervical Cancer"],"prefix":"10.1002","author":[{"given":"Yu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy Fudan University and Key Laboratory of Smart Drug Delivery (Fudan University) Ministry of Education  Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy Fudan University and Key Laboratory of Smart Drug Delivery (Fudan University) Ministry of Education  Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglin","family":"Feng","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Planned Parenthood Research Key Laboratory of Contraceptives and Devices Research (NPFPC) Shanghai Engineer and Technology Research Center of Reproductive Health Drug and Devices  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xia","sequence":"additional","affiliation":[{"name":"Yangtze River Pharmaceutical Group Co., Ltd.  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