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Iguratimod (IGUR), a novel disease\u2010modifying antirheumatic drug (DMARD), has attracted great attention for RA treatment. Due to IGUR\u2019s hydrophobic nature, there\u2019s a pressing need for effective pharmaceutical formulations to enhance bioavailability and therapeutic efficacy. The high\u2010gravity nanoprecipitation technique (HGNPT) emerges as a promising approach for formulating poorly water\u2010soluble drugs. In this study, IGUR nanodrugs (NanoIGUR) are synthesized using HGNPT, with a focus on optimizing various operational parameters. The outcomes revealed that HGNPT enabled the continuous production of NanoIGUR with smaller sizes (ranging from 300 to 1000 nm), more uniform shapes, and reduced crystallinity. In vitro drug release tests demonstrated improved dissolution rates with decreasing particle size and crystallinity. Notably, in vitro and in vivo investigations showcased NanoIGUR\u2019s efficacy in inhibiting synovial fibroblast proliferation, migration, and invasion, as well as reducing inflammation in collagen\u2010induced arthritis. This study introduces a promising strategy to enhance and broaden the application of poorly water\u2010soluble drugs.<\/jats:p>","DOI":"10.1002\/smll.202304150","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T19:07:48Z","timestamp":1700075268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Highly Efficient Oral Iguratimod\/Polyvinyl Alcohol Nanodrugs Fabricated by High\u2010Gravity Nanoprecipitation Technique for Treatment of Rheumatoid Arthritis"],"prefix":"10.1002","volume":"20","author":[{"given":"Cheng","family":"Tao","sequence":"first","affiliation":[{"name":"College of Chemical Engineering Beijing University of Chemical Technology  Beijing 100029 P. R. 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