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Here, RYtov MIcroscopy for Nanoparticles Identification (RYMINI) is introduced, a staining\u2010free, non\u2010invasive, and non\u2010destructive optical approach that is merging holographic label\u2010free 3D tracking with high\u2010sensitivity quantitative phase imaging into a compact optical setup. Dedicated to the identification and then characterization of single nano\u2010object in solution, it is compatible with highly demanding environments, such as level 3 biological laboratories, with high resilience to external source of mechanical and optical noise. Metrological characterization is performed at the level of each single particle on both absorbing and transparent particles as well as on immature and infectious HIV, SARS\u2010CoV\u20102 and extracellular vesicles in solution. The capability of RYMINI to determine the nature, concentration, size, complex refractive index and mass of each single particle without knowledge or model of the particles\u2019 response is demonstrated. The system surpasses 90% accuracy for automatic identification between dielectric\/metallic\/biological nanoparticles and \u224880% for intraclass chemical determination of metallic and dielectric. 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