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However, the existing approaches have unsatisfactory therapeutic effects, which promote the exploration of newer and more effective strategies. MiRNA\u2010modified functional exosomes delivered by dissolvable microneedle arrays (DMNAs) are expected to provide new hope for HS treatment. In this study, a miRNA, miR\u2010141\u20103p, which is downregulated in skin scar tissues and in hypertrophic scar fibroblasts (HSFs), is identified. MiR\u2010141\u20103p mimics inhibit the proliferation, migration, and myofibroblast transdifferentiation of HSFs in vitro by targeting TGF\u2010\u03b22 to suppress the TGF\u2010\u03b22\/Smad pathway. Subsequently, the engineered exosomes encapsulating miR\u2010141\u20103p (miR\u2010141\u20103p\n                    <jats:sup>OE<\/jats:sup>\n                    \u2010Exos) are isolated from adipose\u2010derived mesenchymal stem cells transfected with Lv\u2010miR\u2010141\u20103p. MiR\u2010141\u20103p\n                    <jats:sup>OE<\/jats:sup>\n                    \u2010Exos show the same inhibitive effects as miR\u2010141\u20103p mimics on the pathological behaviors of HSFs in vitro. The DMNAs for sustained release of miR\u2010141\u20103p\n                    <jats:sup>OE<\/jats:sup>\n                    \u2010Exos are further fabricated in vivo. MiR\u2010141\n                    <jats:sup>OE<\/jats:sup>\n                    \u2010Exos@DMNAs effectively decrease the thickness of HS and improve fibroblast distribution and collagen fiber arrangement, and downregulate the expression of \u03b1\u2010SMA, COL\u20101, FN, TGF\u2010\u03b22, and p\u2010Smad2\/3 in the HS tissue. Overall, a promising, effective, and convenient exosome@DMNA\u2010based miRNA delivery strategy for HS treatment is provided.\n                  <\/jats:p>","DOI":"10.1002\/smll.202305374","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T02:53:09Z","timestamp":1695091989000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["MiR\u2010141\u20103p\u2010Functionalized Exosomes Loaded in Dissolvable Microneedle Arrays for Hypertrophic Scar Treatment"],"prefix":"10.1002","volume":"20","author":[{"given":"Sheng","family":"Meng","sequence":"first","affiliation":[{"name":"Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital  Beijing 100853 P. R. China"},{"name":"Chinese PLA Medical School  Beijing 100853 P. R. 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