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Mitigating the secondary inflammatory response following the initial injury is the primary focus of current research in the treatment of SCI. CCL2 (C\u2500C motif chemokine ligand 2) serves as the primary regulator responsible for inflammatory chemotaxis of the majority of peripheral immune cells, blocking the CCL2\u2010CCR2 (C\u2500C chemokine receptor type 2) axis has shown considerable therapeutic potential for\u00a0inflammatory diseases, including SCI. In this study, it presents a multifunctional biomimetic nanoplatform (CCR2\u2010MM@PLGA\/Cur) specifically designed to target the CCL2\u2010CCR2 axis, which consisted of an engineered macrophage membrane (MM) coating with enhanced CCR2 expression and a PLGA (poly (lactic\u2010co\u2010glycolic acid)) nanoparticle that encapsulated therapeutic drugs. CCR2 overexpression on MM not only enhanced drug\u2010targeted delivery to the injury site, but also attenuated macrophage infiltration, microglia pro\u2010inflammatory polarization, and neuronal apoptosis by trapping CCL2. Consequently, it facilitated neural regeneration and motor function recovery in SCI mice, enabling a comprehensive treatment approach for SCI. The feasibility and efficacy of this platform are confirmed through a series of in vitro and in vivo assays, offering new insights and potential avenues for further exploration in the treatment of SCI.<\/jats:p>","DOI":"10.1002\/smll.202305659","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T22:47:44Z","timestamp":1698360464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Engineered Macrophage Membrane\u2010Coated Nanoparticles with Enhanced CCR2 Expression Promote Spinal Cord Injury Repair by Suppressing Neuroinflammation and Neuronal death"],"prefix":"10.1002","volume":"20","author":[{"given":"Changjiang","family":"Gu","sequence":"first","affiliation":[{"name":"Spine Center, Department of Orthopaedics, Changzheng Hospital Naval Medical University (Second Military Medical University)  Shanghai 200003 P. R. 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