{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:51:52Z","timestamp":1788576712535,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073897"],"award-info":[{"award-number":["82073897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373915"],"award-info":[{"award-number":["82373915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seasonal influenza still greatly threatens public health worldwide, leading to significant morbidity and mortality. Antiviral medications for influenza treatment are limited and accompanied by increased drug resistance. In severe influenza virus infection, hyperinflammation and hypoxia may be the significant threats associated with mortality, so the development of effective therapeutic methods to alleviate excessive inflammation while reducing viral damage is highly pursued. Here, a multifunctional MOF\u2010based nanohybrid of Cu\u2500TCPP@Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> as a novel drug against influenza A virus infection (MOF = metal\u2212organic framework; TCPP = tetrakis (4\u2010carboxyphenyl) porphyrin) is designed. Cu\u2500TCPP@Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> exhibits potent inhibitory capability against influenza A virus infection in vitro and in vivo. The mechanism study reveals that Cu\u2500TCPP@Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> inhibits the virus entry by binding to the HA2 subunit of influenza A virus hemagglutinin. In addition, the nanoparticles of Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> in Cu\u2500TCPP@Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> can scavenge intracellular ROS with O<jats:sub>2<\/jats:sub> generation to downregulate inflammatory factors and effectively inhibit cytokines production. By reconstructing the antioxidant microenvironment, Cu\u2500TCPP@Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> features as a promising nanomedicine with anti\u2010inflammatory and anti\u2010viral synergistic effects.<\/jats:p>","DOI":"10.1002\/smll.202306095","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:03:50Z","timestamp":1698699830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Hybrid of Cu\u2500TCPP@Mn<sub>3<\/sub>O<sub>4<\/sub> for Inflammation Relief by ROS Scavenging and O<sub>2<\/sub> Production: An Efficient Strategy for Antiviral Therapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Liu\u2010Rong","family":"Chen","sequence":"first","affiliation":[{"name":"NMPA Key Laboratory for Research and Evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University  Guangzhou 510515 China"},{"name":"Department of Pharmacy The Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital)  Dongguan 523059 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ming","family":"Zou","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Research and Evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010Tian","family":"Li","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Research and Evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Research and Evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye\u2010Hua","family":"Lai","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Research and Evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Research and Evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1789-690X","authenticated-orcid":false,"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Research and Evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"W. 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