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However, the limited intratumoral permeability of nanoparticles is a major hurdle to achieving the desired effect of cancer treatment. Due to their superior cargo towing and reliable penetrating property, micro\u2010\/nanomotors (MNMs) are considered as one of the most potential candidates for the coming generation of drug delivery platforms. Here, near\u2010infrared (NIR)\u2010actuated biomimetic nanomotors (4T1\u2010JPGSs\u2010IND) are fabricated successfully and\u00a0we demonstrate that 4T1\u2010JPGSs\u2010IND selectively accumulate in homologous tumor regions due to the effective homing ability. Upon laser irradiation, hyperthermia generated by 4T1\u2010JPGSs\u2010IND leads to self\u2010thermophoretic motion and photothermal therapy (PTT)\u00a0to ablate tumors with a deep depth, thereby improving the photothermal therapeutic effect for cancer management. The developed nanomotor system with multifunctionalities exhibits promising potential in biomedical applications to fight against various diseases.<\/jats:p>","DOI":"10.1002\/smll.202306208","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T06:38:19Z","timestamp":1693982299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Light\u2010Driven Biomimetic Nanomotors for Enhanced Photothermal Therapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Hong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medicine Ultrasonics Nanfang Hospital Southern Medical University  Guangzhou 510515 China"},{"name":"Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University  Guangzhou 510515 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