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Unfortunately, their applications in nanomedicine are limited by their broad particle size distributions and uncontrolled drug loading due to their multistep synthesis process.\u00a0 Besides, very few attempts at exposing bioactive peptides on apatite NPs are made. In this work, an original one\u2010pot synthesis of well\u2010defined bioactive hybrid NPs composed of a mineral core of bioinspired apatite surrounded by an organic corona of bioactive peptides is reported. Dual stabilizing\u2010bioactive agents, phosphonated polyethylene glycol\u2010peptide conjugates, are prepared and directly used during apatite precipitation i) to form the organic corona during apatite precipitation, driving the size and shape of resulting hybrid NPs with colloidal stabilization and ii) to expose peptide moieties (RGD or YIGSR sequences) at the NPs periphery in view of conferring additional surface properties to enhance their interaction with cells. Here, the success of this approach is demonstrated, the functionalized NPs are fully characterized by Fourier\u2010transform infrared, Raman, X\u2010ray diffraction, solid and liquid state NMR, transmission electron microscopy, and dynamic light scattering, and their interaction with fibroblast cells is followed, unveiling a synergistic proliferative effect.<\/jats:p>","DOI":"10.1002\/smll.202306358","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T07:12:18Z","timestamp":1697094738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["One\u2010Pot Synthesis of Bioinspired Peptide\u2010Decorated Apatite Nanoparticles for Nanomedicine"],"prefix":"10.1002","volume":"20","author":[{"given":"Mathilde","family":"Gu\u00e9rin","sequence":"first","affiliation":[{"name":"IBMM CNRS Universit\u00e9 de Montpellier  1919 Route de Mende Montpellier 34090 France"},{"name":"CIRIMAT CNRS Universit\u00e9 de Toulouse  Ensiacet, 4 allee Emile Monso Toulouse cedex 4 31030 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Lebrun","sequence":"additional","affiliation":[{"name":"IBMM CNRS Universit\u00e9 de Montpellier  1919 Route de Mende Montpellier 34090 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Biomedical Engineering UConn School of Dental Medicine  263 Farmington Avenue, MC1721 Farmington CT 06030\u20101721 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Aza\u00efs","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie de la Mati\u00e8re Condens\u00e9e de Paris Sorbonne Universit\u00e9 and CNRS  4 place Jussieu Paris 75005 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Laurent","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie de la Mati\u00e8re Condens\u00e9e de Paris Sorbonne Universit\u00e9 and CNRS  4 place Jussieu Paris 75005 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Marsan","sequence":"additional","affiliation":[{"name":"CIRIMAT CNRS Universit\u00e9 de Toulouse  Ensiacet, 4 allee Emile Monso Toulouse cedex 4 31030 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Drouet","sequence":"additional","affiliation":[{"name":"CIRIMAT CNRS Universit\u00e9 de Toulouse  Ensiacet, 4 allee Emile Monso Toulouse cedex 4 31030 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4857-4049","authenticated-orcid":false,"given":"Gilles","family":"Subra","sequence":"additional","affiliation":[{"name":"IBMM CNRS Universit\u00e9 de Montpellier  1919 Route de Mende Montpellier 34090 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcrysgrow.2012.11.001"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics8010090"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/26\/1\/064"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42247-019-00063-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/B978-1-78242-033-0.00007-9","volume-title":"Hydroxyapatite (Hap) Biomedical Applications","author":"Bose S.","year":"2015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TB02710F"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-013-5097-9"},{"key":"e_1_2_7_8_1","first-page":"475","volume":"529","author":"Autefage H.","year":"2009","journal-title":"J. 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