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In this work, an elaborate nanoparticle\u2010in\u2010microgel system (\n                    <jats:italic>nM<\/jats:italic>\n                    Gel) is presented for postoperative adhesion prevention.\n                    <jats:italic>nMG<\/jats:italic>\n                    el is facilely formed by crosslinking manganese dioxide (MnO\n                    <jats:sub>2<\/jats:sub>\n                    ) nanoparticles\u2010loaded gelatin microspheres with polydopamine using a modified emulsification\u2010chemical crosslinking method, generating a nano\u2010micron spherical hydrogel. After drying, powdery\n                    <jats:italic>nM<\/jats:italic>\n                    Gel with sprayability can perfectly cover irregular wounds and maintains robust tissue adhesiveness even in a wet environment. Additionally,\n                    <jats:italic>nM<\/jats:italic>\n                    Gel possesses prominent antioxidant and free radical scavenging activity, which protects cell viability and preserves cell biological functions in an oxidative microenvironment. Furthermore,\n                    <jats:italic>nM<\/jats:italic>\n                    Gel displays superior hemostatic property as demonstrated in mouse tail amputation models and liver trauma models. Importantly,\n                    <jats:italic>nM<\/jats:italic>\n                    Gel can be conveniently administrated in a mouse cecal defect model to prevent adhesion between the injured cecum and the peritoneum by reducing inflammation, oxidative stress, collagen synthesis, and angiogenesis. Thus, the bioactive\n                    <jats:italic>nM<\/jats:italic>\n                    Gel offers a practical and efficient approach for ameliorating postsurgical adhesion.\n                  <\/jats:p>","DOI":"10.1002\/smll.202306598","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T13:33:49Z","timestamp":1706708029000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Adhesive Nanoparticle\u2010in\u2010Microgel System with ROS Scavenging Capability and Hemostatic Activity for Postoperative Adhesion Prevention"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0646-5234","authenticated-orcid":false,"given":"Jianmei","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine Medical College Yangzhou University  Yangzhou 225009 P. R. China"},{"name":"Jiangsu Key Laboratory of Experimental &amp; Translational Noncoding RNA Research Medical College Yangzhou University  Yangzhou 225009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"An","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing 210008 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Medical College Yangzhou University  Yangzhou 225009 P. R. China"},{"name":"Jiangsu Key Laboratory of Experimental &amp; Translational Noncoding RNA Research Medical College Yangzhou University  Yangzhou 225009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Zhejiang Shuren University  Hangzhou 310015 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Medical College Yangzhou University  Yangzhou 225009 P. R. China"},{"name":"Jiangsu Key Laboratory of Experimental &amp; Translational Noncoding RNA Research Medical College Yangzhou University  Yangzhou 225009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4141-7462","authenticated-orcid":false,"given":"Zongguang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Physics Science and Technology Yangzhou University  Yangzhou 225009 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.02.026"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9080867"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000395"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12701"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.10.077"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081249"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.11.839"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.08.047"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900809"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.04.003"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.03.110"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c00889"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/C3PY01358H"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01333"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.01.050"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b00791"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c12104"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.111978"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4591384"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c01658"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.07.130"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.04.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112589"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b04022"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.06.037"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.10.013"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn405773r"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.2c00350"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.10.155"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.15376\/biores.11.3.6162-6173"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.12.006"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111589"},{"key":"e_1_2_8_22_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.140554"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201604894"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00545"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.08.018"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b03889"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.03.021"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.02.032"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719114522550"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202104229"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c11206"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c02030"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700859"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c18664"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118100"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1733"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202008395"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201600108"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202306598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202306598","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202306598","content-type":"unspe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