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Previous studies have shown that nanoparticles coated with tumor cell membranes selectively target their homologous tumors. Therefore, this study investigated whether bEnd.3\u2010line BMEC membrane\u2010coated nanoparticles with poly(lactide\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010glycolide)\u2010poly(ethylene glycol)\u2010based doxorubicin\u2010loaded cores (BM\u2010PDs) can be used to target BMECs and cross the BBB. In vitro, the BM\u2010PDs effectively target BMECs and cross a BBB model. The BM\u2010PDs enter the BMECs via macropinocytosis, clathrin\u2010mediated endocytosis, caveolin\u2010mediated endocytosis, and membrane fusion, which result in excellent cellular uptake. The BM\u2010PDs also show excellent cellular uptake in brain tumor cells. In vivo, the BM\u2010PDs target BMECs, cross the BBB, accumulate in brain tumors, and efficiently kill tumor cells. Therefore, the proposed strategy has great therapeutic potential owing to its ability to cross the BBB to reach brain tumors.\n                  <\/jats:p>","DOI":"10.1002\/smll.202306714","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T22:59:05Z","timestamp":1708729145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Nanoparticles Coated with Brain Microvascular Endothelial Cell Membranes can Target and Cross the Blood\u2013Brain Barrier to Deliver Drugs to Brain Tumors"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-8848","authenticated-orcid":false,"given":"Huajian","family":"Chen","sequence":"first","affiliation":[{"name":"The National Key Clinical Specialty The Engineering Technology Research Center of Education Ministry of China Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration Department of Neurosurgery Zhujiang Hospital Southern Medical University  Guangzhou 510282 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingsen","family":"Ji","sequence":"additional","affiliation":[{"name":"The National Key Clinical Specialty The Engineering Technology Research Center of Education Ministry of China Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration Department of Neurosurgery Zhujiang Hospital Southern Medical University  Guangzhou 510282 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine Ultrasonics Nanfang Hospital Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangcai","family":"Luo","sequence":"additional","affiliation":[{"name":"The National Key Clinical Specialty The Engineering Technology Research Center of Education Ministry of China Guangdong 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510282 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Ma","sequence":"additional","affiliation":[{"name":"The National Key Clinical Specialty The Engineering Technology Research Center of Education Ministry of China Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration Department of Neurosurgery Zhujiang Hospital Southern Medical University  Guangzhou 510282 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiquan","family":"Ke","sequence":"additional","affiliation":[{"name":"The National Key Clinical Specialty The Engineering Technology Research Center of Education Ministry of China Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration Department of Neurosurgery Zhujiang Hospital Southern Medical University  Guangzhou 510282 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