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However, methicillin\u2010resistant strains (MRSA) have emerged and can withstand harsh antibiotic treatment. To address this problem, curcumin (CCM) is employed to prepare carbonized polymer dots (CPDs) through mild pyrolysis. Contrary to curcumin, the as\u2010formed CCM\u2010CPDs are highly biocompatible and soluble in aqueous solution. Most importantly, the CCM\u2010CPDs induce the release of neutrophil extracellular traps (NETs) from the neutrophils, which entrap and eliminate microbes. In an MRSA\u2010induced septic mouse model, it is observed that CCM\u2010CPDs efficiently suppress bacterial colonization. Moreover, the intrinsic antioxidative, anti\u2010inflammatory, and anticoagulation activities resulting from the preserved functional groups of the precursor molecule on the CCM\u2010CPDs prevent progression to severe sepsis. As a result, infected mice treated with CCM\u2010CPDs show a significant decrease in mortality even through oral administration. Histological staining indicates negligible organ damage in the MRSA\u2010infected mice treated with CCM\u2010CPDs. It is believed that the in vivo studies presented herein demonstrate that multifunctional therapeutic CPDs hold great potential against life\u2010threatening infectious diseases.\n                  <\/jats:p>","DOI":"10.1002\/smll.202307210","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T02:26:40Z","timestamp":1706322400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Augmenting Neutrophil Extracellular Traps with Carbonized Polymer Dots: A Potential Treatment for Bacterial Sepsis"],"prefix":"10.1002","volume":"20","author":[{"given":"Chin\u2010Jung","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Analytical and Environmental Sciences, National Tsing Hua University  Hsinchu 30013 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsong\u2010Long","family":"Hwang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences Graduate Institute of Natural Products College of Medicine Chang Gung University  Taoyuan 33302 Taiwan"},{"name":"Research Center for Chinese Herbal Medicine Graduate Institute of Healthy Industry Technology College of Human Ecology Chang Gung University of Science and Technology  Taoyuan 33302 Taiwan"},{"name":"Department of Anesthesiology Chang Gung Memorial Hospital  Taoyuan 33302 Taiwan"},{"name":"Department of Chemical Engineering Ming Chi University of Technology  New Taipei City 243303 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Y. 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