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Herein, Cu\/C\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010COOH nanorod composites (Cu\/C\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010COOH) with nanoscale tip convex structures are successfully fabricated as a microwave\u2010responsive smart bacteria\u2010capture\u2010killing vector. Cu\/C\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010COOH exhibited excellent magnetic targeting and bacteria\u2010capturing ability due to its magnetism and high selectivity affinity to the amino groups on the surface of <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:italic>S. aureus<\/jats:italic>). Under microwave irradiation, Cu\/C\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010COOH efficiently treated <jats:italic>S. aureus<\/jats:italic>\u2010infected osteomyelitis through the synergistic effects of microwave thermal therapy, microwave dynamic therapy, and copper ion therapy. It is calculated the electric field intensity in various regions of Cu\/C\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010COOH under microwave irradiation, demonstrating that it obtained the highest electric field intensity on the surface of copper nanoparticles of Cu\/C\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010COOH due to its high\u2010curvature tips and metallic properties. This led to copper nanoparticles attracted more charged particles compared with other areas in Cu\/C\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010COOH. These charges are easier to escape from the high curvature surface of Cu\/C\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010COOH, and captured by adsorbed oxygen, resulting in the generation of reactive oxygen species. The Cu\/C\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010COOH designed in this study is expected to provide insight into the treatment of deep tissue infections under the irradiation of microwave.<\/jats:p>","DOI":"10.1002\/smll.202307406","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:02:08Z","timestamp":1701129728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Smart Bacteria\u2010Capture\u2010Killing Vector for Effectively Treating Osteomyelitis Through Synergy Under Microwave Therapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Jinzhi","family":"Ren","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China Tianjin University  Yaguan Road 135# Tianjin 300072 China"},{"name":"Biomedical Materials Engineering 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