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However, therapeutic strategies that can simultaneously suppress tumors and protect patients from infection have been rarely reported. Here, the use of dual\u2010antigen\u2010displaying nanovaccines (DADNs) is described to elicit synergistic immunoactivation for treating cancer and preventing infectious complications. DADNs are prepared by wrapping immunoadjuvant\u2010loaded nanoparticles with a hybrid coating, which is fused from cell membranes that are separately genetically engineered to express tumor and infectious pathogenic antigens. Due to the presence of a dual\u2010antigen combination, DADNs are able to promote the maturation of dendritic cells and more importantly to trigger cross\u2010presentation of both combined antigens. During in vivo investigations, we\u00a0find that DADNs can reverse immunosuppression by stimulating tumor\u2010associated antigen\u2010specific T\u2010cell responses, resulting in significantly delayed tumor growth in mice. These nanovaccines also elicit effective protective immunity against tumor challenges and induce robust production of pathogenic antigen\u2010specific immunoglobulin G antibody in a prophylactic study. This work offers a unique approach to develop dual\u2010mode vaccines, which are promising for synchronously treating cancer and preventing infection.<\/jats:p>","DOI":"10.1002\/smll.202307748","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T08:48:20Z","timestamp":1701420500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dual\u2010Antigen\u2010Displaying Nanovaccines Elicit Synergistic Immunoactivation for Treating Cancer and Preventing Infectious Complications"],"prefix":"10.1002","volume":"20","author":[{"given":"Fangjie","family":"Chen","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine Institute of Molecular Medicine State Key Laboratory of Systems Medicine for Cancer Renji Hospital School of Medicine Shanghai Jiao Tong University  Shanghai 200127 China"},{"name":"Department of Oncology The First Affiliated 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