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However, it is difficult for AuNPs\u2010LFIA to achieve a wide range and sensitive detection. Herein, novel coral\u2010like hollow gold nanospheres (CHGNPs) are synthesized. The growth of gold nanospheres can be regulated to obtain a multibranched and hollow construction. The obtained CHGNPs possess intense broadband absorption across the visible to near\u2010infrared region, exhibiting a high molar extinction coefficient of 14.65\u00a0\u00d7\u00a010<jats:sup>11<\/jats:sup> M<jats:sup>\u22121<\/jats:sup> cm<jats:sup>\u22121<\/jats:sup> and a photothermal conversion efficiency of 79.75%. Thus, the photothermal\/colorimetric dual\u2010readout LFIA is developed based on CHGNPs (CHGNPs\u2010PT\u2010LFIA and CHGNPs\u2010CM\u2010LFIA) to effectively improve the detection sensitivity and broaden the detection range in regard to sulfonamides (SAs). The limits of detection of the CHGNPs\u2010PT\u2010LFIA and CHGNPs\u2010CM\u2010LFIA reached 1.9 and 2.8\u00a0pg\u00a0mL<jats:sup>\u22121<\/jats:sup> for the quantitative detection of sulfaquinoxaline, respectively, which are 6.3\u2010fold and 4.3\u2010fold lower than that of the AuNPs\u2010LFIA. Meanwhile, the CHGNPs\u2010PT\u2010LFIA broadened the detection range to three orders of magnitude, which ranged from 2.5 to 5000 pg mL<jats:sup>\u22121<\/jats:sup>. The synthesized photothermal CHGNPs have been proven effective in improving the performance of the LFIA and provide a potential option for the construction of sensing platforms.<\/jats:p>","DOI":"10.1002\/smll.202307764","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T09:06:26Z","timestamp":1708333586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Efficient Photothermal Sensor Based on Coral\u2010Like Hollow Gold Nanospheres for the Sensitive Detection of Sulfonamides"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1036-3545","authenticated-orcid":false,"given":"Xiaoyue","family":"Xiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Nanchang University  235 East Nanjing Road Nanchang 330047 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