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This necessitates the development of highly effective therapeutic agents with NIR\u2010II photoresponsivity. Currently, the predominant organic diagnostic agents used in NIR\u2010II PAI\u2010guided PTT are conjugated polymeric materials. However, they exhibit a low in vivo clearance rate and long\u2010term biotoxicity, limiting their clinical translation. In this study, an organic small molecule (CY\u20101234) with NIR\u2010II absorption and nanoencapsulation (CY\u20101234 nanoparticles (NPs)) for PAI\u2010guided PTT is reported. Extended \u03c0\u2010conjugation is achieved in the molecule by introducing donor\u2013acceptor units at both ends of the molecule. Consequently, CY\u20101234 exhibits a maximum absorption peak at 1234\u00a0nm in tetrahydrofuran. Nanoaggregates of CY\u20101234 are synthesized via F\u2010127 encapsulation. They exhibit an excellent photothermal conversion efficiency of 76.01% upon NIR\u2010II light irradiation. After intravenous injection of CY\u20101234 NPs into tumor\u2010bearing mice, strong PA signals and excellent tumor ablation are observed under 1064 nm laser irradiation. This preliminary study can pave the way for the development of small\u2010molecule organic nanoformulations for future clinical applications.<\/jats:p>","DOI":"10.1002\/smll.202307829","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T06:01:56Z","timestamp":1701669716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Small\u2010Molecule Phototheranostic Agent with Extended \u03c0\u2010Conjugation for Efficient NIR\u2010II Photoacoustic\u2010Imaging\u2010Guided Photothermal Therapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Zhen","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organic Electronics and Information Displays &amp; Institute of Advanced Materials (IAM) Jiangsu Key Laboratory for Biosensors Nanjing University of Posts &amp; Telecommunications  Nanjing 210023 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