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Here, a smart copper\u2010based nanocomposite acidic spray has been specifically designed to address this challenge. This copper\u2010based nanocomposite is pH\u2010responsive and has multienzyme\u2010like properties. It enables the spray to effectively eliminate bacteria and alleviate tissue oxidative pressure, thereby accelerating the healing of infected diabetic wounds. The spray works by generating hydroxyl radicals through catalysing H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, which has a high sterilization efficiency of 97.1%. As alkaline micro\u2010vessel leakage neutralizes the acidic spray, this copper\u2010based nanocomposite modifies its enzyme\u2010like activity to eliminate radicals. This reduces the level of reactive oxygen species in diabetic wounds by 45.3%, leading to a similar wound\u2010healing effect between M1 diabetic mice and non\u2010diabetic ones by day 8. 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