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Keratitis treatment requires both the prevention of infection and the reduction of inflammation. However, owing to their limited therapeutic functions, in addition to the ocular barrier, existing conventional medications are characterized by poor efficacy and low bioavailability, requiring high dosages or frequent topical treatment, which represents a burden on patients and increases the risk of side effects. In this study, manganese oxide nanocluster\u2010decorated graphdiyne nanosheets (MnO<jats:sub>x<\/jats:sub>\/GDY) are developed as multienzyme\u2010like nanozymes for the treatment of infectious keratitis and loaded into hyaluronic acid and polymethyl methacrylate\u2010based ocular microneedles (MGMN). MGMN not only exhibits antimicrobial and anti\u2010inflammatory effects owing to its multienzyme\u2010like activities, including oxidase, peroxidase, catalase, and superoxide dismutase mimics but also crosses the ocular barrier and shows increased bioavailability via the microneedle system. Moreover, MGMN is demonstrated to eliminate pathogens, prevent biofilm formation, reduce inflammation, alleviate ocular hypoxia, and promote the repair of corneal epithelial damage in in vitro, ex vivo, and in vivo experiments, thus providing a better therapeutic effect than commercial ophthalmic voriconazole, with no obvious microbial resistance or cytotoxicity.<\/jats:p>","DOI":"10.1002\/smll.202308403","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T09:17:08Z","timestamp":1702631828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Multienzyme\u2010Like Nanozyme Encapsulated Ocular Microneedles for Keratitis Treatment"],"prefix":"10.1002","volume":"20","author":[{"given":"Shen","family":"Liu","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering Qingdao University of Science and Technology  53 Zhengzhou Road Qingdao Shandong 266042 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