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However, the construction of hypoxia\u2010guided BTVs is difficult owing to lack of precise visualization of hypoxic areas. This study synthesizes a hypoxia\u2010responsive T<jats:sub>1<\/jats:sub>, T<jats:sub>2<\/jats:sub>, T<jats:sub>2<\/jats:sub> mapping tri\u2010modal MRI molecular nanoprobe (SPION@ND) and provides precise imaging of hypoxic tumor areas by utilizing the advantageous features of tri\u2010modal magnetic resonance imaging (MRI). SPION@ND exhibits hypoxia\u2010triggered dispersion\u2010aggregation structural transformation. Dispersed SPION@ND can be used for routine clinical BTV construction using T<jats:sub>1<\/jats:sub>\u2010contrast MRI. Conversely, aggregated SPION@ND can be used for tumor hypoxia imaging assessment using T<jats:sub>2<\/jats:sub>\u2010contrast MRI. Moreover, by introducing T<jats:sub>2<\/jats:sub> mapping, this work designs a novel method (adjustable threshold\u2010based hypoxia assessment) for the precise assessment of tumor hypoxia confidence area and hypoxia level. Eventually this work successfully obtains hypoxia tumor target and accurates hypoxia tumor target, and achieves a one\u2010stop hypoxia\u2010guided BTV construction. Compared to the positron emission tomography\u2010based hypoxia assessment, SPION@ND provides a new method that allows safe and convenient imaging of hypoxic tumor areas in clinical settings.<\/jats:p>","DOI":"10.1002\/smll.202308850","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T04:25:25Z","timestamp":1708143925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Contrast\u2010Enhanced Tri\u2010Modal MRI Technique for High\u2010Performance Hypoxia Imaging of Breast Cancer"],"prefix":"10.1002","volume":"20","author":[{"given":"Quanliang","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Radiology First Affiliated Hospital of Ningbo University  59 Liuting Street Ningbo 315010 P. R. 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