{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:26:45Z","timestamp":1787696805218,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ferroptosis therapy, which uses ferroptosis inducers to produce lethal lipid peroxides and induce tumor cell death, is considered a promising cancer treatment strategy. However, challenges remain regarding how to increase the accumulation of reactive oxygen species (ROS) in the tumor microenvironment (TME) to enhance antitumor efficacy. In this study, a hyaluronic acid (HA) encapsulated hollow mesoporous manganese dioxide (H\u2010MnO<jats:sub>2<\/jats:sub>) with double\u2010shell nanostructure is designed to contain iron coordinated cyanine near\u2010infrared dye IR783 (IR783\u2010Fe) for synergistic ferroptosis photodynamic therapy against tumors. The nano photosensitizer IR783\u2010Fe@MnO<jats:sub>2<\/jats:sub>\u2010HA, in which HA actively targets the CD44 receptor, subsequently dissociates and releases Fe<jats:sup>3+<\/jats:sup> and IR783 in acidic TME. First, Fe<jats:sup>3+<\/jats:sup> consumes glutathione to produce Fe<jats:sup>2+<\/jats:sup>, which promotes the Fenton reaction in cells to produce hydroxyl free radicals (\u00b7OH) and induce ferroptosis of tumor cells. In addition, MnO<jats:sub>2<\/jats:sub> catalyzes the production of O<jats:sub>2<\/jats:sub> from H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and enhances the production of singlet oxygen (<jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub>) by IR783 under laser irradiation, thus increasing the production and accumulation of ROS to provide photodynamic therapy. The highly biocompatible IR783\u2010Fe@MnO<jats:sub>2<\/jats:sub>\u2010HA nano\u2010photosensitizers have exhibited tumor\u2010targeting ability and efficient tumor inhibition in vivo due to the synergistic effect of photodynamic and ferroptosis antitumor therapies.<\/jats:p>","DOI":"10.1002\/smll.202309086","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T07:37:27Z","timestamp":1707291447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Study of Iron Complex Photosensitizer with Hollow Double\u2010Shell Nano Structure Used to Enhance Ferroptosis and Photodynamic Therapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Xinrui","family":"Cai","sequence":"first","affiliation":[{"name":"Key Laboratory of Biomedical Functional Materials, School of Science China Pharmaceutical University  Nanjing 211198 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