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This study introduces an innovative inorganic nanosheet, MnO<jats:sub>2<\/jats:sub>\/PDA@Cu, comprising manganese dioxide (MnO<jats:sub>2<\/jats:sub>) loaded with copper ions (Cu) through in situ polymerization using polydopamine (PDA) as an intermediary. Additionally, a specialized methacrylic anhydride modified decellularized cartilage matrix (MDC) hydrogel with chondrogenic effects is developed by modifying a decellularized cartilage matrix with methacrylic anhydride. The MnO<jats:sub>2<\/jats:sub>\/PDA@Cu nanosheet is encapsulated within MDC\u2010derived microneedles, creating a photothermal\u2010controllable MnO<jats:sub>2<\/jats:sub>\/PDA@Cu\u2010MDC microneedle. Effectiveness evaluation involved deep insertion of the MnO<jats:sub>2<\/jats:sub>\/PDA@Cu\u2010MDC microneedle into tracheal orthotopic tumor in a murine model. Under 808\u00a0nm near\u2010infrared irradiation, facilitated by PDA, the microneedle exhibited rapid overheating, efficiently eliminating tumors. PDA's photothermal effects triggered controlled MnO<jats:sub>2<\/jats:sub> and Cu release. The MnO<jats:sub>2<\/jats:sub> nanosheet acted as a potent inorganic nanoenzyme, scavenging reactive oxygen species for an antioxidant effect, while Cu facilitated angiogenesis. This intervention enhanced blood supply at the tumor excision site, promoting stem cell enrichment and nutrient provision. The MDC hydrogel played a pivotal role in creating a chondrogenic niche, fostering stem cells to secrete cartilaginous matrix. In conclusion, the MnO<jats:sub>2<\/jats:sub>\/PDA@Cu\u2010MDC microneedle is a versatile platform with photothermal control, sequentially combining antitumor, antioxidant, pro\u2010angiogenic, and chondrogenic activities to orchestrate precise tracheal tumor eradication and cartilage regeneration.<\/jats:p>","DOI":"10.1002\/smll.202309454","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T08:01:44Z","timestamp":1702627304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Photothermal\u2010Controllable Microneedles with Antitumor, Antioxidant, Angiogenic, and Chondrogenic Activities to Sequential Eliminate Tracheal Neoplasm and Reconstruct Tracheal Cartilage"],"prefix":"10.1002","volume":"20","author":[{"given":"B.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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