{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:48:27Z","timestamp":1790268507533,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21675074"],"award-info":[{"award-number":["21675074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Accurate detection of trace tetracyclines (TCs) in complex matrices is of great significance for food and environmental safety monitoring. However, traditional recognition and amplification tools exhibit poor specificity and sensitivity. Herein, a novel dual\u2010machine linkage nanodevice (DMLD) is proposed for the first time to achieve high\u2010performance analysis of TC, with a padlock aptamer component as the initiation command center, nucleic acid\u2010encoded multispike virus\u2010like Au nanoparticles (nMVANs) as the signal indicator, and cascade walkers circuit as the processor. The existence of spike vertices and interspike nanogaps in MVANs enables intense electromagnetic near\u2010field focusing, allowing distinct surface\u2010enhanced Raman scattering (SERS) activity. Moreover, through the sequential activation between multistage walker catalytic circuits, the DLMD system converts the limited TC recognition into massive engineering assemblies of SERS probes guided by DNA amplicons, resulting in synergistic enhancement of bulk plasmonic hotspot entities. The continuously guaranteed target recognition and progressively promoted signal enhancement ensure highly specific amplification analysis of TC, with a detection limit as low as 7.94 \u00d7 10\n                    <jats:sup>\u221216<\/jats:sup>\n                    \u00a0g mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Furthermore, the reliable recoveries in real samples confirm the practicability of the proposed sensing platform, highlighting the enormous potential of intelligent nanomachines for analyzing the trace hazards in the environment and food.\n                  <\/jats:p>","DOI":"10.1002\/smll.202309502","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T22:42:45Z","timestamp":1706481765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Engineering Assembly of Plasmonic Virus\u2010Like Gold SERS Nanoprobe Guided by Intelligent Dual\u2010Machine Nanodevice for High\u2010Performance Analysis of Tetracycline"],"prefix":"10.1002","volume":"20","author":[{"given":"Xinlin","family":"Xu","sequence":"first","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, Shandong Key Laboratory of Biochemical Analysis, and College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, Shandong Key Laboratory of Biochemical Analysis, and College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, Shandong Key Laboratory of Biochemical Analysis, and College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, Shandong Key Laboratory of Biochemical Analysis, and College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiling","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, Shandong Key Laboratory of Biochemical Analysis, and College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Degang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, Shandong Key Laboratory of Biochemical Analysis, and College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, Shandong Key Laboratory of Biochemical Analysis, and College of Chemistry and Molecular Engineering Qingdao University of Science and Technology  Qingdao 266042 P. R. 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