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Herein, a smart closed\u2010loop system is presented that combines a Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    MXene\u2010based soft contact lens (MX\u2010CLS) sensor, wireless data transmission units, display, and warning components to realize continuous and nondestructive IOP monitoring\/real\u2010time display. The fabricated MX\u2010CLS device exhibits an extremely high sensitivity of 7.483\u00a0mV mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , good linearity on silicone eyeballs, excellent stability under long\u2010term pressure\u2010release measurement, sufficient transparency with 67.8% transmittance under visible illumination, and superior biocompatibility with no discomfort when putting the MX\u2010CLS sensor onto the Rabbit eyes. After integrating with the wireless module, users can realize real\u2010time monitoring and warning of IOP via smartphones, the demonstrated MX\u2010CLS device together with the IOP monitoring\/display system opens up promising platforms for Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    materials as the base for multifunctional contact lens\u2010based sensors and continuous and nondestructive IOP measurement system.\n                  <\/jats:p>","DOI":"10.1002\/smll.202309785","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T14:16:03Z","timestamp":1708438563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["An Ultrasensitive Ti\n                    <sub>3<\/sub>\n                    C\n                    <sub>2<\/sub>\n                    T\n                    <i>\n                      <sub>x<\/sub>\n                    <\/i>\n                    MXene\u2010based Soft Contact Lens for Continuous and Nondestructive Intraocular Pressure Monitoring"],"prefix":"10.1002","volume":"20","author":[{"given":"Zhongyi","family":"Duan","sequence":"first","affiliation":[{"name":"School of Integrated Circuits and Electronics Beijing Institute of Technology  Beijing 100081 P. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Faculty of Hepato\u2010Pancreato\u2010Biliary Surgery Chinese PLA General Hospital Institute of Hepatobiliary Surgery of Chinese PLA &amp; Key Laboratory of Digital Hepatobiliary Surgery  Beijing 100853 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7355-0407","authenticated-orcid":false,"given":"La","family":"Li","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits and Electronics Beijing Institute of Technology  Beijing 100081 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-1647","authenticated-orcid":false,"given":"Guozhen","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits and Electronics Beijing Institute of Technology  Beijing 100081 P. R. 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