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However, the inadequacy of endogenous iron and reactive oxygen species (ROS) restricts the efficacy of ferroptosis. To overcome this obstacle, a near\u2010infrared photo\u2010responsive FeP@PEG NPs is fabricated. Exogenous iron pool can enhance the effect of ferroptosis via the depletion of GSH and further regulate GPX4 inactivation. Generation of \u00b7OH derived from the Fenton reaction is proved by increased accumulation of lipid peroxides. The heat generated by photothermal therapy and ROS generated by photodynamic therapy can enhance cell apoptosis under near\u2010infrared (NIR\u2010808\u00a0nm) irradiation, as evidenced by mitochondrial dysfunction and further accumulation of lipid peroxide content. FeP@PEG NPs can significantly inhibit the growth of several types of cancer cells in vitro and in vivo, which is validated by theoretical and experimental results. Meanwhile, FeP@PEG NPs show excellent T2\u2010weighted magnetic resonance imaging (MRI) property. In summary, the FeP\u2010based nanotheranostic platform for enhanced phototherapy\/ferroptosis\/chemodynamic therapy provides a reliable opportunity for clinical cancer theranostics.<\/jats:p>","DOI":"10.1002\/smll.202309940","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T12:59:36Z","timestamp":1711544376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["FeP\u2010Based Nanotheranostic Platform for Enhanced Phototherapy\/Ferroptosis\/Chemodynamic Therapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Na","family":"An","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Harbin Institute of Technology  Harbin 150001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanglong","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Harbin Institute of 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