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In order to generate effective ferroptosis in tumor cells, iron\u2010based nanomaterials are commonly utilized to introduce foreign iron as a trigger for ferroptosis. However, this usually necessitates the injection of larger doses of iron into the body. These exogenous iron increases are likely to create concealed concerns for symptoms such as liver damage and allergy. Herein, an iron\u2010free radiosensitizer is introduced, oxygen\u2010vacancy\u2010rich MnO\n                    <jats:sub>2<\/jats:sub>\n                    nanoflowers (\n                    <jats:italic>ovs<\/jats:italic>\n                    \u2010MnO\n                    <jats:sub>2<\/jats:sub>\n                    ), that promotes ferroptosis and modifies the tumor microenvironment to assist radiotherapy.\n                    <jats:italic>ovs<\/jats:italic>\n                    \u2010MnO\n                    <jats:sub>2<\/jats:sub>\n                    with enriched oxygen vacancies on the surface induces the release of intracellular free iron (Fe\n                    <jats:sup>2+<\/jats:sup>\n                    ), which functions as an activator of Fenton reaction and enhances the accumulation of intracellular reactive oxygen species. On the other hand, Fe\n                    <jats:sup>2+<\/jats:sup>\n                    also triggers the ferroptosis and promotes the accumulation of lipid peroxides. Subsequently, the depletion of glutathione and accumulation of lipid peroxidation in tumor cells leads to the inactivation of glutathione peroxidase 4 (GPX4) and ferroptosis, thereby enhancing the therapeutic efficacy of radiotherapy. The nanoplatform provides a novel strategy for generating novel nanomedicines for ferroptosis\u2010assisted radiotherapy.\n                  <\/jats:p>","DOI":"10.1002\/smll.202310118","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T09:35:38Z","timestamp":1710927338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Oxygen Vacancy\u2010Rich Manganese Nanoflowers as Ferroptosis Inducers for Tumor Radiotherapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Oncology of The First Affiliated Hospital, Department of Chemistry Jinan University Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Pi","sequence":"additional","affiliation":[{"name":"Department of Oncology of The First Affiliated Hospital, Department of Chemistry Jinan University Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Oncology of The First Affiliated Hospital, Department of Chemistry Jinan University Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology of The First Affiliated Hospital, Department of Chemistry Jinan University Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6953-1342","authenticated-orcid":false,"given":"Tianfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology of The First Affiliated Hospital, Department of Chemistry Jinan University Guangzhou 510632 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