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Herein, smart covalent organic framework (COF) nanoreactors (COF NRs) are constructed by hyaluronic acid (HA) packaged glucose oxidase (GOx) covalently linked Fe\u2010COF for diabetic wound healing. Upon the breakdown of the HA protective layer, GOx consumes glucose to produce gluconic acid and hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>), resulting in decreased local pH and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> supplementation. Density functional theory (DFT) calculations show that Fe\u2010COF has high catalytic activity towards H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, leading to in situ generation of hydroxyl radicals (\u00b7OH) for sterilization, and the localized downregulation of glucose effectively improved the microenvironment of diabetic wounds. Meanwhile, based on the near\u2010infrared photothermal imaging of oxidized 3,3\u2032,5,5\u2032\u2010tetramethylbenzidine (oxTMB), the authors showed that TMB can be applied for the point\u2010of\u2010care testing of \u00b7OH and glucose, and assessing the sterilization progress\u00a0in vivo. More significantly, the facile photothermal signaling strategy can be extended to monitor various ROS\u2010mediated therapeutic systems, enabling accurate prediction of treatment outcomes.<\/jats:p>","DOI":"10.1002\/smll.202310247","type":"journal-article","created":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T02:56:11Z","timestamp":1708224971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Reactive Oxygen\u2010Correlated Photothermal Imaging of Smart COF Nanoreactors for Monitoring Chemodynamic Sterilization and Promoting Wound Healing"],"prefix":"10.1002","volume":"20","author":[{"given":"Xiaohong","family":"Zhu","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules National &amp; Local Joint Engineering Research Center of High\u2010throughput Drug Screening Technology College of Chemistry and Chemical Engineering Hubei University  Wuhan 430062 P. 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