{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:47:21Z","timestamp":1790736441670,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Biohybrid micromotors are active microscopic agents consisting of biological and synthetic components that are being developed as novel tools for biomedical applications. By capturing motile sperm cells within engineered microstructures, they can be controlled remotely while being propelled forward by the flagellar beat. This makes them an interesting tool for reproductive medicine that can enable minimally invasive sperm cell delivery to the oocyte in vivo, as a treatment for infertility. The generation of sperm\u2010based micromotors in sufficiently large numbers, as they are required in biomedical applications has been challenging, either due to the employed fabrication techniques or the stability of the microstructure\u2010sperm coupling. Here, biohybrid micromotors, which can be assembled in a fast and simple process using magnetic microparticles, are presented. These magnetotactic sperm cells show a high motility and swimming speed and can be transferred between different environments without large detrimental effects on sperm motility and membrane integrity. Furthermore, clusters of micromotors are assembled magnetically and visualized using dual ultrasound (US)\/photoacoustic (PA) imaging. Finally, a protocol for the scaled\u2010up assembly of micromotors and their purification for use in in vitro fertilization (IVF) is presented, bringing them closer to their biomedical implementation.<\/jats:p>","DOI":"10.1002\/smll.202310288","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T15:50:52Z","timestamp":1703692252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Magnetotactic Sperm Cells for Assisted Reproduction"],"prefix":"10.1002","volume":"20","author":[{"given":"Friedrich","family":"Striggow","sequence":"first","affiliation":[{"name":"Micro\u2010 and NanoBiomedical Engineering Group (MNBE) Institute for Emerging Electronic Technologies Leibniz Institute for Solid State and Materials Research (IFW)  01069 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Micro\u2010 and NanoBiomedical Engineering Group (MNBE) Institute for Emerging Electronic Technologies Leibniz Institute for Solid State and Materials Research (IFW)  01069 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azaam","family":"Aziz","sequence":"additional","affiliation":[{"name":"Micro\u2010 and NanoBiomedical Engineering Group (MNBE) Institute for Emerging Electronic Technologies Leibniz Institute for Solid State and Materials Research (IFW)  01069 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Nauber","sequence":"additional","affiliation":[{"name":"Micro\u2010 and NanoBiomedical Engineering Group (MNBE) Institute for Emerging Electronic Technologies Leibniz Institute for Solid State and Materials Research (IFW)  01069 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Hebenstreit","sequence":"additional","affiliation":[{"name":"Micro\u2010 and NanoBiomedical Engineering Group (MNBE) Institute for Emerging Electronic Technologies Leibniz Institute for Solid State and Materials Research (IFW)  01069 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver G.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Research Center for Materials Architectures and Integration of Nanomembranes (MAIN) Chemnitz University of Technology  09126 Chemnitz Germany"},{"name":"Faculty of Physics TU Dresden  01062 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6149-3732","authenticated-orcid":false,"given":"Mariana","family":"Medina\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Micro\u2010 and NanoBiomedical Engineering Group (MNBE) Institute for Emerging Electronic Technologies Leibniz Institute for Solid State and Materials Research (IFW)  01069 Dresden Germany"},{"name":"Chair of Micro\u2010 and NanoSystems Center for Molecular Bioengineering (B CUBE) Technische Universit\u00e4t Dresden  01307 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem046"},{"key":"e_1_2_9_2_1","first-page":"308","volume":"91","author":"Lindsay T. 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