{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:22:26Z","timestamp":1792264946537,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M701082"],"award-info":[{"award-number":["2021M701082"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["192102210021"],"award-info":[{"award-number":["192102210021"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immunotherapy utilizing anti\u2010PD\u2010L1 blockade has achieved dramatic success in clinical breast cancer management but is often hampered by the limited immune response. Increasing evidence shows that immunogenic cell death (ICD) recently arises as a promising strategy for enlarging tumor immunogenicity and eliciting systemic anti\u2010tumor immunity effectively. However, developing simple but versatile, highly efficient but low\u2010toxic, biosafe, and clinically available transformed ICD inducers remains a huge demand and is highly desirable. Herein, a multifunctional ICD inducer is purposefully developed A6\u2010MPDA@PAL by integrating photothermal therapy (PTT) nanoplatforms mesoporous polydopamine (MPDA), CDK4\/6 inhibitor palbociclib (PAL), and CD44\u2010specific targeting A6 peptide in a simple way for augmenting the immune antitumor efficacy of anti\u2010PD\u2010L1 therapy. Remarkably, the light\u2010inducible nanoplatforms exhibit multiple favorable therapeutic features ensuring a superior and biosafe PTT\/chemotherapy efficacy. Together with stronger accumulative ICD induction, single administration of A6\u2010MPDA@PAL can trigger robust systemic antitumor immunity and abscopal effect with the assistance of anti\u2010PD\u2010L1 blockade by fascinating the intratumoral infiltration of T lymphocytes and reversing the immunosuppressive tumor microenvironment simultaneously, therapy achieving brilliant synergistic immunotherapy with effective tumor ablation. This study presents a simple and smart ICD inducer opening up attractive clinical possibilities for reinforcing the anti\u2010PD\u2010L1 therapy against breast cancer.<\/jats:p>","DOI":"10.1002\/smll.202310565","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T22:55:39Z","timestamp":1708728939000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mesoporous polydopamine Targeting CDK4\/6 Inhibitor toward Brilliant Synergistic Immunotherapy of Breast Cancer"],"prefix":"10.1002","volume":"20","author":[{"given":"Conglei","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immune Engineering Henan University  Kaifeng Henan 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immune Engineering Henan University  Kaifeng Henan 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immune Engineering Henan University  Kaifeng Henan 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6526-3616","authenticated-orcid":false,"given":"Jianjun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immune Engineering Henan University  Kaifeng Henan 475004 China"},{"name":"State Key Laboratory of Antiviral Drugs Henan University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5051-0530","authenticated-orcid":false,"given":"Jiahua","family":"Shi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immune Engineering Henan University  Kaifeng Henan 475004 China"},{"name":"State Key Laboratory of Antiviral Drugs Henan University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6896-0847","authenticated-orcid":false,"given":"Guanhua","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immune Engineering Henan University  Kaifeng Henan 475004 China"},{"name":"State Key Laboratory of Antiviral Drugs Henan University  China"},{"name":"Chinese Academy of Medical Science and Peking Union Medical College  Beijing 100050 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau6584"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.05.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202212118"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.05.031"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.06.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121433"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12499"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004481"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.73566"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11269-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.08.024"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.03.059"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b12788"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c10590"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201902960"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.6b01994"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.05.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202000261"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl5838"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.04.045"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12864"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23465"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30642-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101890"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17996-7"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202010637"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NR00487A"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR04278E"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40843-022-2140-7"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b08051"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.11.014"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201904742"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.021.202101222"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6528\/abf4a9"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c19214"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-020-00474-6"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.06.008"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2303"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6NR03398A"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c13164"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42399-9"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00858-8"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-020-02609-5"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.740002"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203788"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.14"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b07233"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0014-x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-2990"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.11.051"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202310565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T02:03:20Z","timestamp":1736820200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202310565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":50,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/smll.202310565"],"URL":"https:\/\/doi.org\/10.1002\/smll.202310565","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,23]]},"assertion":[{"value":"2023-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2310565"}}