{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:58:29Z","timestamp":1792468709924,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720220022"],"award-info":[{"award-number":["20720220022"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["B16029"],"award-info":[{"award-number":["B16029"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute pancreatitis (AP) is a potentially life\u2010threatening inflammatory disease that can lead to the development of systemic inflammatory response syndrome and its progression to severe acute pancreatitis. Hence, there is an urgent need for the rational design of highly efficient antioxidants to treat AP. Herein, an optimized Cu\u2010based metal\u2013organic framework (MOF) nanozyme with exceptional antioxidant activity is introduced, designed to effectively alleviate AP, by engineering the metal coordination centers in MN2Cl2 (M\u00a0=\u00a0Co, Ni, Cu). Specifically, the Cu MOF, which benefits from a Cu active center similar to that of natural superoxide dismutase (SOD), exhibited at least four times higher SOD\u2010like activity than the Ni\/Co MOF. Theoretical analyses further demonstrate that the CuN2Cl2 site not only has a moderate adsorption effect on the substrate molecule \u2022OOH but also reduces the dissociation energy of the product H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . Additionally, the Cu MOF nanozyme possesses the excellent catalase\u2010like activity and \u2022OH removal ability. Consequently, the Cu MOF with broad\u2010spectrum antioxidant activity can efficiently scavenge reactive oxygen species to alleviate arginine\u2010induced AP. More importantly, it can also mitigate apoptosis and necrosis of acinar cells by activating the PINK1\/PARK2\u2010mediated mitophagy pathway. This study highlights the distinctive functions of tunable MOF nanozymes and their potential bio\u2010applications.\n                  <\/jats:p>","DOI":"10.1002\/smll.202310675","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T02:30:36Z","timestamp":1710556236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Precise Control of Metal Active Sites of Metal\u2013Organic Framework Nanozymes for Achieving Excellent Enzyme\u2010Like Activity and Efficient Pancreatitis Therapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325000 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizhao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325000 P. R. China"},{"name":"Wenzhou Medical University  Wenzhou Zhejiang 325000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Physics Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Laboratory for Soft Functional Materials Research Xiamen University  Xiamen 361005 P. R. 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