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Curcumin is a promising drug for ICH treatment due to its multiple biological activities, but its application is limited by its poor watersolubility and instability. Herein, platelet membrane\u2010coated curcumin polylactic\u2010co\u2010glycolic acid (PLGA) nanoparticles (PCNPs) are prepared to achieve significantly improved solubility, stability, and sustained release of curcumin. Fourier transform infrared spectra and X\u2010ray diffraction assays indicate good encapsulation of curcumin within nanoparticles. Moreover, it is revealed for the first time that curcumin\u2010loaded nanoparticles can not only suppress hemin\u2010induced astrocyte proliferation but also induce astrocytes into neuron\u2010like cells in vitro. PCNPs are used to treat rat ICH by tail vein injection, using in situ administration as control. The results show that PCNPs are more effective than curcumin\u2010PLGA nanoparticles in concentrating on hemorrhagic lesions, inhibiting inflammation, suppressing astrogliosis, promoting neurogenesis, and improving motor functions. The treatment efficacy of intravenously administered PCNPs is comparable to that of in situ administration, indicating a good targeting effect of PCNPs on the hemorrhage site. This study provides a potent treatment for hemorrhagic injuries and a promising solution for efficient delivery of water\u2010insoluble drugs using composite materials of macromolecules and cell membranes.<\/jats:p>","DOI":"10.1002\/smll.202311128","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T06:25:59Z","timestamp":1718691959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Platelet Membrane\u2010Coated Curcumin\u2010PLGA Nanoparticles Promote Astrocyte\u2010Neuron Transdifferentiation for Intracerebral Hemorrhage Treatment"],"prefix":"10.1002","volume":"20","author":[{"given":"Ximing","family":"Xu","sequence":"first","affiliation":[{"name":"School of Pharmacy Jiangsu University, The International Institute on Natural Products and Stem Cells (iNPS), Key Lab for Drug Delivery &amp; Tissue Regeneration Jiangsu Provincial Research Center for Medicinal Function Development 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