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Current diagnostic and therapeutic methods focus on late\u2010stage amyloid fibrils and plaques, overlooking toxic soluble amyloid \u03b2 oligomers (A\u03b2Os) accumulating early in AD. A multifunctional liposome\u2010based platform is designed for early diagnosis and therapy of AD, leveraging a novel self\u2010assembled cyclic\n                    <jats:sc>d<\/jats:sc>\n                    ,\n                    <jats:sc>l<\/jats:sc>\n                    \u2010\u03b1\u2010peptide (\n                    <jats:bold>CP\u20102<\/jats:bold>\n                    ) that selectively targets A\u03b2Os. Biocompatible\n                    <jats:bold>CP\u20102<\/jats:bold>\n                    conjugated liposomes (CP\u20102\u2010LPs) effectively disrupt A\u03b2 aggregation and mitigate A\u03b2\u2010mediated toxicity in human neuroblastoma cells. In transgenic\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    AD models, CP\u20102\u2010LPs significantly outperformed free\n                    <jats:bold>CP\u20102<\/jats:bold>\n                    by improving cognitive and behavioral functions, extending lifespan, and reducing toxic A\u03b2O levels. Intravenous injection of fluorescently labeled CP\u20102\u2010LPs reveals effective blood\u2010brain barrier penetration, with significantly higher brain fluorescence in transgenic mice than WT, enabling precise diagnosis. These findings underscore CP\u20102\u2010LPs as a valuable tool for early detection and targeted therapy in AD.\n                  <\/jats:p>","DOI":"10.1002\/smll.202311670","type":"journal-article","created":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T15:55:35Z","timestamp":1710086135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Multifunctional Liposomes Targeting Amyloid\u2010\u03b2 Oligomers for Early Diagnosis and Therapy of Alzheimer's Disease"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-5980","authenticated-orcid":false,"given":"Sudipta","family":"Senapati","sequence":"first","affiliation":[{"name":"Department of Chemistry Bar\u2010Ilan University  Ramat\u2010Gan 5290002 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4850-0218","authenticated-orcid":false,"given":"Kuldeep","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Bar\u2010Ilan University  Ramat\u2010Gan 5290002 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadeja","family":"Awad","sequence":"additional","affiliation":[{"name":"Department of Chemistry Bar\u2010Ilan University  Ramat\u2010Gan 5290002 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3210-1645","authenticated-orcid":false,"given":"Shai","family":"Rahimipour","sequence":"additional","affiliation":[{"name":"Department of Chemistry Bar\u2010Ilan University  Ramat\u2010Gan 5290002 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,10]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.22027"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12328"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq160"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4245"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.09.075"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.03.035"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1372"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2101"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-179941"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04533"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53415-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0535-7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3432-04.2004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.09.018"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00737-w"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00540-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.24494"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.862369"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4161"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3407"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01481-w"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00139-y"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042110"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2018.9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c05470"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00199"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2020.08.008"},{"key":"e_1_2_8_28_1","author":"Akasaka T.","year":"2023","journal-title":"J. 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