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Traditional self\u2010gelling powders, while beneficial due to their ease of application and rapid action, fall short in such challenging conditions. To bridge this gap, the research introduces a novel self\u2010gelling powder that combines ultrafast covalent gelation and robust wet adhesion, presenting a significant advancement in acute hemorrhage control. This ternary system comprises <jats:italic>\u03b5<\/jats:italic>\u2010polylysine (<jats:italic>\u03b5<\/jats:italic>\u2010PLL) and 4\u2010arm polyethylene glycol succinyl succinate (4\u2010arm\u2010PEG\u2010NHS) forming the hydrogel framework. Na<jats:sub>2<\/jats:sub>HPO<jats:sub>4<\/jats:sub> functions as the \u201cH<jats:sup>+<\/jats:sup> sucker\u201d to expedite the amidation reaction, slashing gelation time to under 10 s, crucial for immediate blood loss restriction. Moreover, PEG chains' hydrophilicity facilitates efficient absorption of interfacial blood, increasing the generated hydrogel's cross\u2010linking density and strengthens its tissue bonding, thereby resulting in excellent mechanical and wet adhesion properties. In vitro experiments reveal the optimized formulation's exceptional tissue compliance, procoagulant activity, biocompatibility and antibacterial efficacy. In porcine models of heart injuries and arterial punctures, it outperforms commercial hemostatic agent Celox, confirming its rapid and effective hemostasis. Conclusively, this study presents a transformative approach to hemostasis, offering a reliable and potent solution for the emergency management of massive hemorrhage.<\/jats:p>","DOI":"10.1002\/smll.202311859","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:01:02Z","timestamp":1713693662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Swift Covalent Gelation Coupled with Robust Wet Adhesive Powder: A Novel Approach for Acute Massive Hemorrhage Control in Dynamic and High\u2010Pressure Wound Environments"],"prefix":"10.1002","volume":"20","author":[{"given":"Kangli","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education School of Material Science and Engineering Frontiers Science Center for Materiobiology and Dynamic Chemistry East China University of Science and Technology  Shanghai 200237 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