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However, how the ligand\u2010anchors of nano\u2010chaperones affect the spatial conformational changes in proteins remains unclear, limiting the development of efficient nano\u2010chaperones. In this study, three types of gold nanoparticles (AuNPs) with different core\/ligands interface anchor structures (Au\u2500NH\u2500R, Au\u2500S\u2500R, and Au\u2500C\u2261C\u2500R, R = benzoic acid) are synthesized as an ideal model to investigate the effect of interfacial anchors on A\u03b2 and amylin fibrillization. Computational results revealed that the distinct interfacial anchors imparted diverse distributions of electrostatic potential on the nanointerface and core\/ligands bond strength of AuNPs, leading to differential interactions with amyloid peptides. Experimental results demonstrated that all three types of AuNPs exhibit site\u2010specific inhibitory effects on A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    fibrillization due to preferential binding. For amylin, amino\u2010anchored AuNPs demonstrate strong adsorption to multiple sites on amylin and effectively inhibit fibrillization. Conversely, thiol\u2010 and alkyne\u2010anchored AuNPs adsorb at the head region of amylin, promoting folding and fibrillization. This study not only provided molecular insights into how core\/ligands interfacial anchors of nanomaterials induce spatial conformational changes in amyloid peptides but also offered guidance for precisely engineering artificial\u2010chaperones' nanointerfaces to regulate the conformational transformation of proteins.\n                  <\/jats:p>","DOI":"10.1002\/smll.202312046","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T08:50:11Z","timestamp":1717404611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Engineering Core\/Ligands Interfacial Anchors of Nanoparticles for Efficiently Inhibiting Both A\u03b2 and Amylin Fibrillization"],"prefix":"10.1002","volume":"20","author":[{"given":"Yuzhou","family":"Deng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology  122 Luoshi Road Wuhan 430070 P. 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