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In this work, its utilization for organic photoelectrochemical transistor (OPECT) detection of the important cancer biomarker of neuron\u2010specific enolase (NSE) is reported. A MOF@COF@CdS quantum dots (QDs) heterojunction is rationally designed to serve as the photogating module against the polymeric channel. Linking with a sandwich complexing event, target\u2010dependent alternation of the photogate is achieved, leading to the changed photoelectric conversion efficiency as indicated by the amplified OPECT signals. The proposed assay demonstrates good analytical performance in detecting NSE, featuring a linear detection range from 0.1\u00a0pg\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    to 100\u00a0ng\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , with a detection limit of 0.033\u00a0pg\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/smll.202400033","type":"journal-article","created":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T16:14:14Z","timestamp":1709482454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Reticular Heterojunction for Organic Photoelectrochemical Transistor Detection of Neuron\u2010Specific Enolase"],"prefix":"10.1002","volume":"20","author":[{"given":"Lu","family":"Hou","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yancheng Institute of Technology  Yancheng 224051 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical and Chemical Engineering Taizhou University  Taizhou 318000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen\u2010Ying","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yancheng Institute of Technology  Yancheng 224051 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze\u2010Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yancheng Institute of Technology  Yancheng 224051 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical and Chemical Engineering Taizhou University  Taizhou 318000 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