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Compared with traditional methods, optoelectronic stimulation can better preserve the structural integrity and genetic content of the retina. However, enhancing the spatiotemporal accuracy of stimulation is challenging. Quantum dot\u2010doped ZnIn\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    microflowers (MF) are utilized to construct a biomimetic photoelectric interface with a 0D\/3D heterostructure, aiming to restore the light response in PR\u2010degenerative mice. The MF bio interface has dimensions similar to those of natural PRs and can be distributed within the curved spatial region of the retina, mimicking cellular dispersion. The soft 2D nano petals of the MF provide a large specific surface area for photoelectric activation and simulate the flexibility interfacing between cells. This bio interface can selectively restore the light responses of seven types of retina ganglion cells that encode brightness. The distribution of responsive cells forms a pattern similar to that of normal mice, which may reflect the generation of the initial \u201cneural code\u201d in the degenerative retina. Patch\u2010clamp recordings indicate that the bio interface can induce spiking and postsynaptic currents at the single\u2010neuron level. The results will shed light on the development of a potential bionic subretinal prosthetic toolkit for visual function restoration.\n                  <\/jats:p>","DOI":"10.1002\/smll.202400300","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T08:31:56Z","timestamp":1719390716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Photoreceptor\u2010Mimetic Microflowers for Restoring Light Responses in Degenerative Retina through a 2D Nanopetal\/Cell Biointerface"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-5573","authenticated-orcid":false,"given":"Gerile","family":"Oudeng","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering The Hong Kong Polytechnic University  Hung Hom Kowloon Hong Kong SAR 999077 P. R. 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