{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:56:24Z","timestamp":1792205784444,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32222046"],"award-info":[{"award-number":["32222046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Doxorubicin (DOX) is widely used as a chemotherapeutic agent for both hematologic and solid tumors and is a reasonable candidate for glioma treatment. However, its effectiveness is hindered by significant toxicity and drug resistance. Moreover, the presence of the blood\u2013brain barrier (BBB) brings a crucial challenge to glioma therapy. In response, a GSH\u2010responsive and actively targeted nanoprodrug delivery system (cRGD\/PSDOX\u2010Cur@NPs) are developed. In this system, a disulfide bond\u2010bridged DOX prodrug (PEG\u2010SS\u2010DOX) is designed to release specifically in the high glutathione (GSH) tumor environment, markedly reducing the cardiotoxicity associated with DOX. To further address DOX resistance, curcumin, serving as a P\u2010glycoprotein (P\u2010gp) inhibitor, effectively increased cellular DOX concentration. Consequently, cRGD\/PSDOX\u2010Cur@NPs exhibited synergistic anti\u2010tumor effects in vitro. Furthermore, in vivo experiments validated the superior BBB penetration and brain\u2010targeting abilities of cRGD\/PSDOX\u2010Cur@NPs, showcasing the remarkable potential for treating both subcutaneous and orthotopic gliomas. This research underscores that this nanoprodrug delivery system presents a novel approach to inhibiting glioma while addressing resistance and systemic toxicity.<\/jats:p>","DOI":"10.1002\/smll.202400630","type":"journal-article","created":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T16:06:43Z","timestamp":1709482003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["A Targeted and Responsive Nanoprodrug Delivery System for Synergistic Glioma Chemotherapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Weiling","family":"Zhuo","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine West China Second University Hospital Sichuan University  Chengdu 610041 China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of Education  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxin","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linbin","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjie","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Gou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Chen","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Huang","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Sun","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-5072","authenticated-orcid":false,"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer Center West China Hospital West China Medical School Sichuan University and Collaborative Innovation Center for Biotherapy  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120784"},{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c09968"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.10.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab072"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30990-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043330"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20220052"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2021.100796"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2919"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09864"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00894-3"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202301271"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.05.003"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202314025"},{"key":"e_1_2_7_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202207535"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-022-01266-2"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101454"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2009.07.001"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2023.101205"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2014.11.008"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.02.011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-020-00764-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.10.074"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04437-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c04996"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-023-01472-w"},{"key":"e_1_2_7_15_3","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202301231"},{"key":"e_1_2_7_15_4","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20200027"},{"key":"e_1_2_7_15_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2024.109344"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34744-1"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114463"},{"key":"e_1_2_7_17_1","first-page":"26","volume":"9","author":"Guo Q.\u2010L.","year":"2022","journal-title":"Mil Med Res"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20200129"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014944"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.07.002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12255"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.06.021"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3776"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.11.020"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101840"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202202558"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4087"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202301656"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119666"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn402662d"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304187"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.12.056"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.101007"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007426"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202903"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.10.022"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01258-7"},{"key":"e_1_2_7_29_3","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos139"},{"key":"e_1_2_7_29_4","doi-asserted-by":"publisher","DOI":"10.7150\/thno.50613"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00641-0"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01392-3"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2289"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114648"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28741-7"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.07.025"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202400630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T02:04:51Z","timestamp":1736820291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202400630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,3]]},"references-count":60,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/smll.202400630"],"URL":"https:\/\/doi.org\/10.1002\/smll.202400630","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,3]]},"assertion":[{"value":"2024-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400630"}}