{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:21:01Z","timestamp":1790216461410,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T00:00:00Z","timestamp":1716076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005153","name":"China National Funds for Distinguished Young Scientists","doi-asserted-by":"publisher","award":["51925104"],"award-info":[{"award-number":["51925104"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173251"],"award-info":[{"award-number":["52173251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232338"],"award-info":[{"award-number":["7232338"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Currently, methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA)\u2010induced osteomyelitis is a clinically life\u2010threatening disease, however, long\u2010term antibiotic treatment can lead to bacterial resistance, posing a huge challenge to treatment and public health. In this study, glucose\u2010derived carbon spheres loaded with zinc oxide (ZnO@HTCS) are successfully constructed. This composite demonstrates the robust ability to generate reactive oxygen species (ROS) under ultrasound (US) irradiation, eradicating 99.788% \u00b1 0.087% of MRSA within 15\u00a0min and effectively treating MRSA\u2010induced osteomyelitis infection. Piezoelectric force microscopy tests and finite element method simulations reveal that the ZnO@HTCS composite exhibits superior piezoelectric catalytic performance compared to pure ZnO, making it a unique piezoelectric sonosensitizer. Density functional theory calculations reveal that the formation of a Mott\u2013Schottky heterojunction and an internal piezoelectric field within the interface accelerates the electron transfer and the separation of electron\u2013hole pairs. Concurrently, surface vacancies of the composite enable the adsorption of a greater amount of oxygen, enhancing the piezoelectric catalytic effect and generating a substantial quantity of ROS. This work not only presents a promising approach for augmenting piezoelectric catalysis through construction of a Schottky heterojunction interface but also provides a novel, efficient therapeutic strategy for treating osteomyelitis.<\/jats:p>","DOI":"10.1002\/smll.202400732","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T05:45:28Z","timestamp":1716183928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Ultrasound\u2010Triggered Piezoelectric Catalysis of Zinc Oxide@Glucose Derived Carbon Spheres for the Treatment of MRSA Infected Osteomyelitis"],"prefix":"10.1002","author":[{"given":"Yihao","family":"Guo","sequence":"first","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan 430062 China"},{"name":"School of Health Science &amp; Biomedical Engineering Hebei University of Technology  Xiping Avenue 5340# Tianjin 300401 China"},{"name":"School of Materials Science &amp; Engineering Peking University  Yiheyuan Road 5# Beijing 100871 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congyang","family":"Mao","sequence":"additional","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan 430062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1270-1870","authenticated-orcid":false,"given":"Shuilin","family":"Wu","sequence":"additional","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan 430062 China"},{"name":"School of Health Science &amp; Biomedical Engineering Hebei University of Technology  Xiping Avenue 5340# Tianjin 300401 China"},{"name":"School of Materials Science &amp; Engineering Peking University  Yiheyuan Road 5# Beijing 100871 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Health Science &amp; Biomedical Engineering Hebei University of Technology  Xiping Avenue 5340# Tianjin 300401 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Materials Science &amp; Engineering Peking University  Yiheyuan Road 5# Beijing 100871 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan 430062 China"},{"name":"School of Health Science &amp; Biomedical Engineering Hebei University of Technology  Xiping Avenue 5340# Tianjin 300401 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,19]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00686-0"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16727-5"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2019.07.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00084-17"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2022.110428","volume":"249","author":"Zhong C.","year":"2022","journal-title":"Compos. Part B Eng."},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2008.04.012"},{"key":"e_1_2_8_5_1","volume":"10","author":"Wang X.","year":"2023","journal-title":"Adv. Sci."},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102926"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202204437"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00362-4"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202005062"},{"key":"e_1_2_8_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202308437"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2022.101065"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2022.100976"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18268-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c03424"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104843"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.34133\/research.0096"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00403D"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211130"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202212259"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2022.12.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-020-2992-5"},{"key":"e_1_2_8_14_2","volume":"35","author":"Mao C.","year":"2023","journal-title":"Adv. Mater."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202303195"},{"key":"e_1_2_8_15_2","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1039\/C9CS00648F","volume":"11","author":"Son S.","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214087"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202306493"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202300022"},{"key":"e_1_2_8_17_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214540"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00648F"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208256"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202110429"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2022.107141"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202301349"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202212259"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202304162"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09189"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2023.108311"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120075"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2023.122623"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201603497"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-015-0040-x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b17351"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf0854"},{"key":"e_1_2_8_30_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.09.019"},{"key":"e_1_2_8_30_4","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201900322"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2021.105938"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2015.01.032"},{"key":"e_1_2_8_31_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2014.06.008"},{"key":"e_1_2_8_31_4","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210296"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304262"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jechem.2017.08.013"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biombioe.2020.105949"},{"key":"e_1_2_8_34_1","volume":"13","author":"Wei X.","year":"2023","journal-title":"Adv. Energy Mater."},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100919"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2023.123325"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2017.07.033"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2022.06.013"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9QI00454H"},{"key":"e_1_2_8_39_1","volume":"116","author":"Ye K.","year":"2019","journal-title":"Trends Anal. Chem."},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.124751"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2021.150106"},{"key":"e_1_2_8_40_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201704567"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/aenm.202303027"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100919"},{"key":"e_1_2_8_41_3","volume":"116","author":"Ye K.","year":"2019","journal-title":"Trends Anal. Chem."},{"key":"e_1_2_8_41_4","volume":"31","author":"Hao L.","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.124371"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2020.119294"},{"key":"e_1_2_8_42_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300648"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2023.156477"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2020.105259"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202001976"},{"key":"e_1_2_8_44_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23921-3"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.113074"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00591-z"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202400732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T05:45:35Z","timestamp":1716183935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202400732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,19]]},"references-count":78,"alternative-id":["10.1002\/smll.202400732"],"URL":"https:\/\/doi.org\/10.1002\/smll.202400732","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,19]]},"assertion":[{"value":"2024-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400732"}}