{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:59:10Z","timestamp":1790099950134,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2023YFC3402800"],"award-info":[{"award-number":["2023YFC3402800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82120108016"],"award-info":[{"award-number":["82120108016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071987"],"award-info":[{"award-number":["82071987"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010010","name":"Shanxi Province Science Foundation for Youths","doi-asserted-by":"publisher","award":["20210302124035"],"award-info":[{"award-number":["20210302124035"]}],"id":[{"id":"10.13039\/501100010010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010010","name":"Shanxi Province Science Foundation for Youths","doi-asserted-by":"publisher","award":["20210302124285"],"award-info":[{"award-number":["20210302124285"]}],"id":[{"id":"10.13039\/501100010010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontitis is the leading cause of adult tooth missing. Thorny bacterial biofilm and high reactive oxygen species (ROS) levels in tissue are key elements for the periodontitis process. It is meaningful to develop an advanced therapeutic system with sequential antibacterial\/ antioxidant ability to meet the overall goals of periodontitis therapy. Herein, a dual\u2010polymer functionalized melanin\u2010AgNPs (P\/D\u2010MNP\u2010Ag) with biofilm penetration, hydroxyapatite binding, and sequentially treatment ability are fabricated. Polymer enriched with 2\u2010(Dimethylamino)ethyl methacrylate (D), can be protonated in an acid environment with enhanced positive charge, promoting penetration in biofilm. The other polymer is rich in phosphate group (P) and can chelate Ca<jats:sup>2+<\/jats:sup>, promoting the polymer to adhere to the hydroxyapatite surface. Melanin has good ROS scavenging and photothermal abilities, after in situ reduction Ag, melanin\u2010AgNPs composite has sequentially transitioned between antibacterial and antioxidative ability due to heat and acid accelerated Ag<jats:sup>+<\/jats:sup> release. The released Ag<jats:sup>+<\/jats:sup> and heat have synergistic antibacterial effects for bacterial killing. With Ag<jats:sup>+<\/jats:sup> consumption, the antioxidant ability of MNP recovers to scavenge ROS in the inflammatory area. When applied in the periodontitis model, P\/D\u2010MNP\u2010Ag has good therapeutical effects to ablate biofilm, relieve inflammation state, and reduce alveolar bone loss. P\/D\u2010MNP\u2010Ag with sequential treatment ability provides a reference for developing advanced oral biofilm eradication systems.<\/jats:p>","DOI":"10.1002\/smll.202400771","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T05:05:33Z","timestamp":1715835933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Dual\u2010Polymer Functionalized Melanin\u2010AgNPs Nanocomposite with Hydroxyapatite Binding Ability to Penetrate and Retain in Biofilm Sequentially Treating Periodontitis"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7031-934X","authenticated-orcid":false,"given":"Bing","family":"Cao","sequence":"first","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University  Taiyuan 030032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of Education Taiyuan University of Technology  Taiyuan 030024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfei","family":"Ma","sequence":"additional","affiliation":[{"name":"The Radiology Department of Shanxi Provincial People's Hospital Five Hospital of Shanxi Medical University  Taiyuan 030001 China"},{"name":"College of Medical Imaging Shanxi Medical University  Taiyuan 030001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Department of Physiology School of Basic Medical Sciences Shanxi Medical University  Taiyuan 030001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"li","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University  Taiyuan 030032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University  Taiyuan 030032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghai","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine and Food Engineering Shanxi University of Chinese Medicine  Taiyuan 030024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhen","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of Education Taiyuan University of Technology  Taiyuan 030024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6922-0747","authenticated-orcid":false,"given":"Ruiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Radiology Department of Shanxi Provincial People's Hospital Five Hospital of Shanxi Medical University  Taiyuan 030001 China"},{"name":"College of Medical Imaging Shanxi Medical University  Taiyuan 030001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31146-8"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13506"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05923"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12732"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.09.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-021-00647-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26195905"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b02816"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12114"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b03237"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b18301"},{"key":"e_1_2_9_10_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.08.038"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c02702"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.05.051"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.132491"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202101040"},{"key":"e_1_2_9_12_3","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02124-6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b04022"},{"key":"e_1_2_9_13_2","author":"Zheng Y.","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.143292"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.213158"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01940"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.04.003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.6418"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70199-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12342"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.04.015"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn507170s"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0420-1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c02055"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120341"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.03.006"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c02150"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.05.034"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01221A"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c22512"},{"key":"e_1_2_9_26_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2021.102510"},{"key":"e_1_2_9_26_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2023.213333"},{"key":"e_1_2_9_26_5","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201502201"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NA00236D"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA08356C"},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","unstructured":"a)C.Chen G.Chu W.He Y.Liu K.Dai J.Valdez A.Moores P.Huang Z.Wang J.Jin M.Guan W.Jiang Y.Mai D.Ma Y.Wang Y.Zhou Adv. Mater2023 35 2207950;","DOI":"10.1002\/adma.202207950"},{"key":"e_1_2_9_29_2","doi-asserted-by":"crossref","unstructured":"b)Y.Chang Y.Feng Y.Cheng R.Zheng X.Wu H.Jian D.Zhang Z.Tang Z.Wang J.Hao H.Zhang Adv. Sci2019 6 1900158;","DOI":"10.1002\/advs.201900158"},{"key":"e_1_2_9_29_3","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c06652"},{"key":"e_1_2_9_29_4","doi-asserted-by":"crossref","unstructured":"d)X.Qi Y.Huang S.You Y.Xiang E.Cai R.Mao W.Pan X.Tong W.Dong F.Ye J.Shen Adv. Sci2022 9 2106015.","DOI":"10.1002\/advs.202106015"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.0c00757"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00953-10"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2014.10.027"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203291"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2013.12.020"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201802008"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5b02212"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202400771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T10:18:08Z","timestamp":1744539488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202400771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,15]]},"references-count":52,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/smll.202400771"],"URL":"https:\/\/doi.org\/10.1002\/smll.202400771","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,15]]},"assertion":[{"value":"2024-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400771"}}