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Herein, hierarchical Ag\u2010ZnIn<jats:sub>2<\/jats:sub>S<jats:sub>4<\/jats:sub> (Ag\u2010ZIS) core\u2010shell nanowires are synthesized by in situ Metal\u2010Organic Framework derived method for efficient PDT of Candida albicans (C. albicans). The core\u2010shell structure enables spatial synergy strategy to regulate the charge transfer pathway under visible light excitation, in which the Ag nanowires are like the highway for the photogenerated electrons. The enhanced charge carrier separation efficiency greatly increased the chances for the generation of ROS. As expected, the optimized Ag\u2010ZIS nanowires exhibit excellent performance for inactivation of C. albicans under visible light irradiation (<jats:italic>\u03bb<\/jats:italic> \u2265 420 nm, 15 min), and the effective sterilization concentration is as high as 10<jats:sup>7<\/jats:sup>CFU mL<jats:sup>\u20101<\/jats:sup>. Moreover, in vivo infection experiments suggested that the PDT effect of Ag\u2010ZIS nanowires on the mouse wound healing is better than that of the clinical Ketoconazole drug. The PDT antifungal mechanism of Ag\u2010ZIS nanowires is also investigated, and superoxide anion is found to be the predominant active species to causes C. albicans damage. This work provides a new perspective for designing novel interface structures to regulate charge transfer to achieve efficient PDT antifungal therapy.<\/jats:p>","DOI":"10.1002\/smll.202400867","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T12:21:15Z","timestamp":1716294075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Regulation of Charge Transfer Pathway in Ag\u2010ZnIn<sub>2<\/sub>S<sub>4<\/sub> Nanowires for Visible Photodynamic Therapy on Candida Albicans Infections"],"prefix":"10.1002","author":[{"given":"Xiaoyu","family":"Sun","sequence":"first","affiliation":[{"name":"Photoelectric Conversion Energy Materials and Devices Key Laboratory of Anhui Province Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education School of Material Science and Engineering &amp; School of Life Sciences Anhui University  Hefei 230601 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lebing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Photoelectric Conversion Energy Materials and Devices Key Laboratory of Anhui Province Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education School of Material Science and Engineering &amp; School of Life Sciences Anhui University  Hefei 230601 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Photoelectric Conversion Energy Materials and Devices Key Laboratory of Anhui Province Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education School of Material Science and Engineering &amp; School of Life Sciences Anhui University  Hefei 230601 P. R. 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